52532-96-4

Basic information

• Product Name: N-benzyl-2-(4-methoxyphenyl)acetamide
• Synonyms: N-benzyl-2-(4-methoxyphenyl)acetamide
• CAS NO: 52532-96-4
• Molecular Formula: C₁₆H₁₇NO₂
• Molecular Weight: 255.31168
• Mol File: 52532-96-4.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-benzyl-2-(4-methoxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2-(4-methoxyphenyl)acetamide(52532-96-4)
• EPA Substance Registry System: N-benzyl-2-(4-methoxyphenyl)acetamide(52532-96-4)

Safety Data

• Hazardous Substances Data: 52532-96-4(Hazardous Substances Data)

Upstream product

• 104-01-8 4-Methoxyphenylacetic acid 
• 100-46-9 benzylamine 
• 6832-17-3 2-diazo-1-(4-methoxyphenyl)ethanone 
• 702-23-8 2-(4-Methoxyphenyl)ethanol 
• 7461-34-9 N-benzyl-p-chlorobenzamide 
• 19350-72-2 N'-(4-methoxybenzylidene)-4-methylbenzenesulfonohydrazide 
• 13939-06-5 molybdenum hexacarbonyl 
• 123-11-5 4-methoxy-benzaldehyde 
• 3287-99-8 benzylamine hydrochloride 
• 768-60-5 4-methoxyphenylacetylen 
• 6343-93-7 2-(4-methoxyphenyl)acetamide 
• 100-51-6 benzyl alcohol 
• 14062-18-1 ethyl p-methoxyphenylacetate 

Relevant articles and documents

Deoxyfluorination of Carboxylic Acids with CpFluor: Access to Acyl Fluorides and Amides

3,3-Difluoro-1,2-diphenylcyclopropene (CpFluor), a bench-stable fluorination reagent, has been developed in the deoxyfluorination of carboxylic acids to afford various acyl fluorides. This all-carbon-based fluorination reagent enabled the efficient transformation of (hetero)aryl, alkyl, alkenyl, and alkynyl carboxylic acids to the corresponding acyl fluorides under the neutral conditions. This deoxyfluorination method was featured by the synthesis of acyl fluorides with in-situ formed CpFluor, as well as the one-pot amidation reaction of carboxylic acids via in-situ formed acyl fluorides.

Graphene oxide: A convenient metal-free carbocatalyst for facilitating amidation of esters with amines

Herein, we report a graphene oxide (GO) catalyzed condensation of non-activated esters and amines, that can enable diverse amides to be synthesized from abundant ethyl esters forming only volatile alcohol as a by-product. GO accelerates ester to amide conversion in the absence of any additives, unlike other catalysts. A wide range of ester and amine substrates are screened to yield the respective amides in good to excellent yields. The improved catalytic activity can be ascribed to the oxygenated functionalities present on the graphene oxide surface which forms H-bonding with the reactants accelerating the reaction. Improved yields and a wide range of functional group tolerance are some of the important features of the developed protocol.

Solvent-Free N-Alkylation of Amides with Alcohols Catalyzed by Nickel on Silica–Alumina

The N-alkylation of phenylacetamide with benzyl alcohol has been studied using Ni/SiO2–Al2O3. In the optimized conditions, the desired product was isolated in an excellent 98 % yield. The reaction could advantageously be performed in neat conditions, with a slight excess of amide and a catalytic amount of base. These conditions were tested on a large range of amides and alcohols, affording 24 compounds in 13 to 99 % isolated yields.