52568-28-2Relevant articles and documents
Stereoselective Synthesis of Chiral β-Fluoro α-Amino Acids via Pd(II)-Catalyzed Fluorination of Unactivated Methylene C(sp3)-H Bonds: Scope and Mechanistic Studies
Zhang, Qi,Yin, Xue-Song,Chen, Kai,Zhang, Shuo-Qing,Shi, Bing-Feng
, p. 8219 - 8226 (2015)
The synthesis of fluorinated complex molecules via direct C(sp3)-H fluorination is attractive yet remains challenging. Here we describe the Pd(II)-catalyzed fluorination of unactivated methylene C(sp3)-H bonds by an inner-sphere mech
Copper-Mediated Thiolation of Unactivated Heteroaryl C?H Bonds with Disulfides under Ligand- and Metal-Oxidant-Free Conditions
Li, Ya,Liu, Yue-Jin,Shi, Bing-Feng
, p. 4117 - 4121 (2017)
Various sulfenylated heteroarenes were synthesized by a copper-mediated C?H thiolation, which was assisted by a 2-(pyridin-2-yl)isopropylamine (PIP-amine) directing group. The reaction features a broad substrate scope, good functional group tolerance, ligand- and metal-oxidant-free conditions, exceptional compatibility with aliphatic disulfides, and excellent yields, providing a highly efficient approach to the biologically important sulfenylated heteroarenes. (Figure presented.).
HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS
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Paragraph 0405-0406, (2020/08/05)
Aminopyrazine compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in onco
Palladium-Catalyzed Electrochemical C-H Bromination Using NH4Br as the Brominating Reagent
Yang, Qi-Liang,Wang, Xiang-Yang,Wang, Tong-Lin,Yang, Xiang,Liu, Dong,Tong, Xiaofeng,Wu, Xin-Yan,Mei, Tian-Sheng
supporting information, p. 2645 - 2649 (2019/04/17)
The palladium-catalyzed electrochemical C-H bromination of benzamide derivatives under divided cells is developed, in which NH4Br serves as a brominating reagent and electrolyte. The protocol avoids the use of chemical oxidants and provides an alternative method for the synthesis of aryl bromides.