52584-39-1

Basic information

• Product Name: 5-ETHYL-5-P-TOLYLBARBITURIC ACID 99+%
• Synonyms: 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(4-methylphenyl)-;5-Ethyl-5-(4-methylphenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione;Barbituric acid, 5-ethyl-5-p-tolyl;5-ETHYL-5-P-TOLYLBARBITURIC ACID 99+%;5-ethyl-5-P-tolylbarbituric acid;5-ethyl-5,4'-tolylbarbituric acid;Tolylbarb;5-(4-Methylphenyl)-5-ethylbarbituric acid
• CAS NO: 52584-39-1
• Molecular Formula: C13H14N2O3
• Molecular Weight: 246.26186
• EINECS: 258-023-9
• Mol File: 52584-39-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 177-178 °C(lit.)
• Appearance: /
• Density: 1.204g/cm³
• Refractive Index: 1.538
• CAS DataBase Reference: 5-ETHYL-5-P-TOLYLBARBITURIC ACID 99+%(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ETHYL-5-P-TOLYLBARBITURIC ACID 99+%(52584-39-1)
• EPA Substance Registry System: 5-ETHYL-5-P-TOLYLBARBITURIC ACID 99+%(52584-39-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 52584-39-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H14N2O3/c1-3-13(9-6-4-8(2)5-7-9)10(16)14-12(18)15-11(13)17/h4-7H,3H2,1-2H3,(H2,14,15,16,17,18)

Upstream product

• 2518-72-1 5-ethyl barbituric acid 
• 3076-56-0 p-tolyllead triacetate 

Relevant articles and documents

The Chemistry of Aryllead(IV) Tricarboxylates. Reaction with Derivatives of Malonic Acid: New Routes to α-Aryl Carboxylic Acids and Arylated Barbituric Acid Derivatives

Derivatives of 2,2-dimethyl-1,3-dioxan-4,6-dione (Meldrum's acid) and the sodium salts of substituted malonic esters undergo electrophilic C-arylation in high yield with aryllead triacetates, thus providing new routes to α-arylalkanoic acids.Syntheses of the antiflammatory compound 2-(p-isobutylphenyl)propanoic acid (Ibuprofen) have been carried out to demonstrate the method.The arylation reaction has been extended to 5-ethylbarbituric acid and to barbituric acid itself, which affords the 5,5-diarylated derivatives in good yield.A study of the effect of some tertiary bases on the reaction of p-methoxyphenyllead triacetate with the 5-isopropyl derivative of Meldrum's acid has shown that replacement of pyridine by 2,2'-bipyridyl results in an increase in yield and reaction rate, while a further marked improvement occurs in the presence of 1,10-phenanthroline.