526-25-0Relevant articles and documents
Promising Antifungal and Antibacterial Agents Based on 5-Aryl-2,2′-bipyridines and Their Heteroligand Salicylate Metal Complexes: Synthesis, Bioevaluation, Molecular Docking
Borisevich, Sophia,Burgart, Yanina,Charushin, Valery,Chupakhin, Oleg,Evstigneeva, Natalia,Gerasimova, Natalia,Kopchuk, Dmitry,Kungurov, Nikolai,Saloutin, Victor,Savchuk, Maria,Shchegolkov, Evgeny,Shchur, Irina,Ulitko, Maria,Zilberberg, Natalia,Zyryanov, Grigory
supporting information, (2021/12/01)
A series of new 5-aryl-2,2′-bipyridines and their (polyfluoro)salicylate complexes of Cu(II), Co(II) and Mn(II) were synthesized. Their antimicrobial activity was evaluated in vitro against six strains of Trichophytons, E. floccosum, M. canis, C. ablicans and Gram-negative bacteria N. gonorrhoeae. Among azo-ligands, Ph-bipy and Tol-bipy showed promising antifungal activity (minimum inhibitory concentration (MIC)4?2H)2(Tol-bipy)2] suppressed the growth of seven Candida strains at MIC 12–24 μM. [Cu(Sal?2H)(Ph-bipy)] and [Cu(SalF3?2H)(Ph-bipy)2] showed the promising anti-gonorrhoeae activity (MIC 4.2–5.2 μM). (Cu(SalFn?2H)(Tol-bipy)2], [Cu(SalF4?2H)(Ph-bipy)2] and [Cu(SalF3?2H)(Ph-bipy)2]) were found active against the bacteria of S. aureus, S. aureus MRSA and their biofilms (MIC 2.4–41.4 μM). The most active compounds were tested for toxicity in vitro against human embryonic kidney (HEK-293) cells and in vivo experiments with CD-1 mice.
Reactions Catalysed by a Binuclear Copper Complex: Aerobic Cross Dehydrogenative Coupling of N-Aryl Tetrahydroisoquinolines
Liu, Yuxia,Wang, Chao,Xue, Dong,Xiao, Miao,Li, Chaoqun,Xiao, Jianliang
supporting information, p. 3051 - 3061 (2017/03/13)
Binuclear copper complex [{Cu(Sal)2(NCMe)}2] (Sal=salicylate) was found to be an active catalyst for the aerobic oxidation of N-aryl tetrahydroisoquinolines to the corresponding iminium ions, which could be trapped by a wide range of nucleophiles to form coupled products. The reactions took place under 1 bar of O2 at room temperature with 1 mol % of the copper catalyst being sufficient in most cases, and are considerably accelerated by catalytic chloride anions. Mechanistic studies show that the CuII dimer oxidizes the amine to the iminium ion, and this two-electron process requires O2, whereby the resulting CuI is concomitantly reoxidised back to CuII. Various lines of evidence suggest that the oxidative coupling reaction is turnover-limited by the step of iminium formation, and it is this step that is promoted by the chloride anion. Since it is more efficient than and mechanistically distinct from the well-studied simple copper salts such as CuBr and CuCl2, the binuclear copper catalyst provides a new tool for oxidative coupling reactions.
Relationship between the structures of Cu(II) complexes and their chemical transformations. XII. Are there only the split - off bonds activated during dehydration of copper carboxylates?
Langfelderova,Hodur
, p. 1009 - 1023 (2008/10/08)
The study of the thermal dehydration of the compounds CuX2nH2O, where X- were formate, salicylate or phtalate anions, was performed, including the observations of structural changes of compounds during their decomposition.
