52602-38-7Relevant articles and documents
SUBSTITUTED TETRAHYDROBENZOPYRROLYL-FURANOIC ACID DERIVATIVES AS PHOSPHOLIPASE A2 INHIBITORS
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, (2008/06/13)
Compounds of the formula wherein R is hydrogen, alkyl1-8, geminal alkyl1-3, un-substituted or substituted aryl; X is alkylene, ?CR1=CR2? (E and/or Z), carbonyl, oxygen or sulfur, wherein one of Ri and R2 is alkyli.3 and the other is hydrogen; Y is unsubstituted alkyh-n or substituted by one or more alkyl1-3 groups, or unsubstituted or substituted phenylalkyl 1-3; or a salt thereof with a pharmaceutically acceptable base, are described. The compound of formula I are potent inhibitors of phospholipase A2 (PLA2) and are therefore useful in the treatment of inflammatory diseases, such as, psoriasis, inflammatory bowel disease, asthma, allergy, arthritis, dermatitis, gout, pulmonary, myocardial ischemia and trauma induced inflammation, such as, spinal cord injury