5264-21-1Relevant articles and documents
Preparation method of indenoisoquinoline derivative
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Paragraph 0095-0098; 0127; 0128; 0134; 0135, (2019/05/28)
The invention relates to a preparation method of an indenoisoquinoline derivative as shown in formula (I). The preparation method includes the steps of (A), providing a first reactant as shown in formula (II) and a second reactant as shown in formula (III
Design, docking, and synthesis of novel indeno[1,2-c]isoquinolines for the development of antitumor agents as topoisomerase I inhibitors
Cho, Won-Jea,Le, Quynh Manh,My Van, Hue Thi,Youl Lee, Kwang,Kang, Bok Yun,Lee, Eung-Seok,Lee, Sang Kook,Kwon, Youngjoo
, p. 3531 - 3534 (2008/02/07)
An intramolecular radical cyclization reaction of 4-bromo-3-arylisoquinolines 11a-c allowed the efficient synthesis of 11-methylindenoisoquinolines 2a-c. 5-(2-Aminoethylamino)indeno[1,2-c]isoquinolin-11-one 4 was also prepared in the convenient manner. Th
Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone
Jagtap, Prakash G.,Baloglu, Erkan,Southan, Garry J.,Mabley, Jon G.,Li, Hongshan,Zhou, Jing,Van Duzer, John,Salzman, Andrew L.,Szabó, Csaba
, p. 5100 - 5103 (2007/10/03)
Novel indeno[1,2-c]isoquinolinone derivatives were synthesized and evaluated as inhibitors of the nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1). These potent non-mutagenic PARP-1 inhibitors possess an additional five-membered ring between the B an