52641-32-4

Basic information

• Product Name: Carbamic acid, [(1S)-2-chloro-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester
• CAS NO: 52641-32-4
• Molecular Formula: C17H16ClNO3
• Molecular Weight: 317.772
• Mol File: 52641-32-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-2-chloro-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-2-chloro-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester(52641-32-4)
• EPA Substance Registry System: Carbamic acid, [(1S)-2-chloro-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester(52641-32-4)

Safety Data

• Hazardous Substances Data: 52641-32-4(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 63-91-2 L-phenylalanine 
• 1161-13-3 N-Cbz-L-Phe 

Downstream Products

• 17187-05-2 Z-L-phenylalanylglycinamide 
• 118234-92-7 (S)-2-Benzyloxycarbonylamino-3-phenyl-propionic acid (S)-1-tert-butoxycarbonyl-ethyl ester 
• 50466-66-5 (Z)-(S)-Phe-(S)-Ala-OBzl 
• 83361-25-5 N^α-Z-fenilalanil-N-(1-fenil-3-metil)-5-pirazolilammide 
• 7669-64-9 (2S)-1-((2S)-2-[[(benzyloxy)carbonyl]amino]-3-phenylpropanoyl)tetrahydro-1H-pyrrole-2-carboxylic acid 
• 1207718-73-7 (S,E)-ethyl-5-(2-benzyloxycarbonylamino-3-phenylpropionyloxy)pent-2-enoate 
• 59830-60-3 benzyl (1S)-(1-formyl-2-phenylethyl)carbamate 
• 684212-67-7 2-benzyloxycarbonylamino-3-phenyl-thiopropionic acid S-dodecyl ester 
• 14825-82-2 L-phenylalanine-N-carboxyanhydride 
• 1043922-50-4 (S)-benzyl (1-(1,2-dimethylhydrazinyl)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 1043922-53-7 benzyl (S)-(1-(2-cyano-1,2-dimethylhydrazinyl)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 133010-22-7 benzyl (S)-(1-fluoro-1-oxo-3-phenylpropan-2-yl)carbamate 
• 769922-77-2 (S)-benzyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 5001-55-8 (S)-2-amino-N-((2S,3S,4R,5R)-5-(6-(dimethylamino)-9H-purine9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)-3-phenylpropanamide 

Relevant articles and documents

Hybrids of arenobufagin and benzoisoselenazol reducing the cardiotoxicity of arenobufagin

Arenobufagin is a naturally occurring bufadienolide showing promising antitumor activity accompanied however with apparent cardiac toxicity. Following the recent discovery that oxidative damage possibly be an important cause of the cardiac toxicity of cardenolides, a strategy fusing the antitumor agent arenobufagin with a benzoisoselenazol fragment, a reactive oxygen species (ROS) scavenger, has been developed. Six novel hybrids were synthesized and their ROS scavenging activities as well as their in vitro cytotoxicity against the human hepatocellular carcinoma cell line HepG2, an adriamycin-resistant subline HepG2/ADM, and the human myocardial cell line AC16 were evaluated. The results indicate that the hybrids exhibit various degrees of in vitro ROS scavenging activities, and weaker cytotoxicity than that of arenobufagin against the myocardial cell line AC16. These findings suggest the feasibility of a strategy in which the cardiotoxicity of the potential antitumor agent arenobufagin is reduced.

Polypeptide dendrimers: Self-assembly and drug delivery

Amphiphilic dendritic poly(glutamic acid)-b-polyphenylalanine copolymers were synthesized using generation 3 dendritic poly(glutamic acid) as the macroinitiator in the ring-opening polymerization of NCA-Phe. The block copolymers self-assembled micelles with polyphenylalanine segments as core and dendritic poly(glutamic acid) segments as shell. The biocompatibility of the micelles was studied. The release of the anticancer drug doxorubicin from the micelles was investigated in vitro. The results showed that the sustaining release of the drug could last for 60 h. The micellar drug release system was efficient in inhibiting the proliferation of HepG2 liver cancer cells, 75% cancer cells were killed under appropriate in vitro incubation.

Synthesis of N-urethane protected β-amino alcohols employing N-(protected-α-aminoacyl)benzotriazoles

A simple and racemisation-free synthesis of N-urethane protected α-amino/peptidyl alcohols by the reduction of the corresponding easily accessible N-acylbenzotriazoles is described. The method is practical, straightforward, fast and efficient for the synt