5267-40-3

Basic information

• Product Name: N-[(4-chlorophenyl)(phenyl)methyl]acetamide
• Synonyms: N-[(4-chlorophenyl)(phenyl)methyl]acetamide
• CAS NO: 5267-40-3
• Molecular Weight: 259.735
• Mol File: 5267-40-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-[(4-chlorophenyl)(phenyl)methyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(4-chlorophenyl)(phenyl)methyl]acetamide(5267-40-3)
• EPA Substance Registry System: N-[(4-chlorophenyl)(phenyl)methyl]acetamide(5267-40-3)

Safety Data

• Hazardous Substances Data: 5267-40-3(Hazardous Substances Data)

Upstream product

• 119-56-2 (4-chlorophenyl)phenylmethanol 
• 75-05-8 acetonitrile 
• 831-81-2 4-chlorophenyl(phenyl)methane 
• 75-36-5 acetyl chloride 
• 5267-39-0 4-chlorobenzhydrylamine hydrochloride 

Relevant articles and documents

Air-stable Bis(pentamethylcyclopentadienyl) Zirconium Perfluorooctanesulfonate as an Efficient and Recyclable Catalyst for the Synthesis of N-substituted Amides

Bis(pentamethylcyclopentadienyl) zirconium perfluorooctanesulfonate is an air-stable and water-tolerant Lewis acid. This complex exhibited good thermal stability and high solubility in polar organic solvents. The compound showed relatively strong acidity, with an acid strength of 0.8Ho≤3.3, and high catalytic efficiency for the synthesis of N-substituted amides via the reaction of carboxylic acids with amines, the Ritter reaction of nitriles with alcohols, and the amination of alcohols with amides. Moreover, the complex had good reusability. This catalytic system affords a simple and efficient way to synthesize N-substituted amides.

Method for preparing amide from aryl methane derivative and nitrile

The invention provides a simple and efficient method for directly preparing an amide compound from an aryl methane derivative and nitrile. In the method, manganese triacetate dihydrate is used as a catalyst, and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone(DDQ) is used as an oxidizing agent. The method has the characteristics that raw materials are cheap and easy to obtain, the source of the nitrile is wide, reaction conditions are mild, the applicability is wide and the like. The method solves the problems that ceric ammonium nitrate (CAN) and a fluorine agent which are used by a method for directly synthesizing amide by using aryl methane and nitrile compounds are hard to treat, atomic economy is poor, the source of the nitrile is narrow and the like.

The ritter reaction under truly catalytic bronsted acid conditions

Simple organic acids like 2,4-dinitrobenzenesulfonic acid (DNBSA) catalyze the Ritter reaction of secondary benzylic alcohols giving rise to the corresponding N-benzylacetamides in usually high yields. Reactions can be conducted without exclusion of oxygen and without the need of dry solvents. With tertiary α,α-dimethylbenzylic alcohols a different pathway involving a formal dimerization reaction takes place under the acid-catalytic conditions used. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.