52705-43-8

Basic information

• Product Name: alpha-hydroxybenzylphosphinic acid
• Synonyms: alpha-hydroxybenzylphosphinic acid;(α-Hydroxybenzyl)phosphinic acid;α-Hydroxybenzylphosphinic acid;a-Hydroxybenzylphosphinic Acid;DPQYARCVTAMMLE-UHFFFAOYSA-N
• CAS NO: 52705-43-8
• Molecular Formula: C₇H₉O₃P
• Molecular Weight: 172.118321
• EINECS: 258-116-4
• Mol File: 52705-43-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 110°
• Boiling Point: 369.1°Cat760mmHg
• Flash Point: 177°C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: alpha-hydroxybenzylphosphinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: alpha-hydroxybenzylphosphinic acid(52705-43-8)
• EPA Substance Registry System: alpha-hydroxybenzylphosphinic acid(52705-43-8)

Safety Data

• Hazardous Substances Data: 52705-43-8(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 56547-85-4 O-trimethylsilyl [phenyl(trimethylsiloxy)methyl]phosphonite 
• 6303-21-5 hypophosphorous acid 
• 760133-36-6 1-hydroxy-1-phenylmethyl-1,1-bis(H-phosphinic acid) 

Downstream Products

• 1127-41-9 (α-hydroxybenzyl)phosphonic acid 
• 6881-57-8 benzylphosphonic acid 
• 102-07-8 bis(diphenyl)urea 
• 100-52-7 benzaldehyde 
• 1013036-09-3 C₁₁H₁₅O₄P 
• 1013036-08-2 C₉H₁₃O₄P 
• 913943-35-8 N,N-dimethylaminomethane-P-(1-hydroxyphenylmethyl)phosphinic acid 
• 1367728-72-0 N-benzyl-N-methylaminomethane-P-(1-hydroxyphenylmethyl)phosphinic acid 

Relevant articles and documents

1-hydroxy-1,1-bis(H-phosphinates): Synthesis, stability, and sorption properties

A synthesis of 1-hydroxy-1,1-bis(H-phosphinates) from acylchlorides is described. Solid-state structures of two bis(phosphinates) determined by X-ray diffraction showed variations in the Pi-C distances. The compounds show negligible sorption on hydroxyapatite and an intermediate chemical stability in aqueous solution. The hydrolysis occurs in acidic as well as alkaline media. Hydrolysis rates of four derivatives show the lowest stability for aromatic derivatives as a result of the electron-withdrawing effect. Main products of hydrolysis are 1-hydroxy-(H-phosphinates) and phosphorous acid.

Three component Kabachnik-Fields condensation leading to substituted aminomethane-P-hydroxymethylphosphonic acids as atool for screening of bacterial urease inhibitors

Condensation of hydroxyalkane-H-phosphinic acids, formaldehyde and secondary amines has given entry to the synthesis of variously substituted aminomethane-P-hydroxymethylphosphinic acids. The proposed strategy allowed to perform a feasible synthesis of several molecules with designed biological activity towards bacterial urease - an enzyme which is a medicinally relevant molecular target. The inhibitory potency of compounds was validated using enzyme purified from Bacillus pasteurii. ARKAT-USA, Inc.

Asymmetrically substituted phosphinic acids

The invention relates to asymmetrically substituted phosphinic acids of the formula (I) [in-line-formulae]R1R2C(OH)—P(═O)(OX)—C(OH)R3R4 ??(I)[/in-line-formulae] in which X is hydrogenR1, R2, R3, and R4 are identical or different and are hydrogen, alkyl, alkenyl, alkynyl, aralkyl, aryl and/or alkaryl,with the proviso that the respective R1R2C(OH)— and —C(OH)R3R4 groups are always different, to a process for their preparation, and to their use.