52715-14-7Relevant articles and documents
Hydroxylated terphenylphosphine ligands for palladium-catalyzed ortho-selective cross-coupling of dibromophenols, dibromoanilines, and their congeners with Grignard reagents
Ishikawa, Shunpei,Manabe, Kei
experimental part, p. 10156 - 10163 (2012/02/13)
p-Terphenylphosphines bearing one or two hydroxy groups were used as ligands to palladium in the cross-coupling of dibromophenols, dibromoanilines, and their congeners with Grignard reagents. High ortho-selectivity that cannot be achieved using other phosphine ligands was observed. ortho-Preference was also observed in competitive cross-coupling reactions of two substrates. A significant effect of the concentration of the Grignard reagent on the ortho-selectivity was observed, when the hydroxylated terphenylphosphines were used. Kinetic studies on this effect showed that high concentrations of the Grignard reagent retard the cross-coupling reaction only at the para-position, but not at the ortho-position.
Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs
Shrestha, Suja,Bhattarai, Bharat Raj,Lee, Keun-Hyeung,Cho, Hyeongjin
, p. 6535 - 6548 (2008/04/12)
A series of compounds containing one or two salicylic acid moieties were synthesized, and their efficacy to inhibit the phosphohydrolase activity of PTP1B examined. Some of the methylenedisalicylic acid derivatives were potent inhibitors of PTP1B. Of those derivatives, 3c exhibited about a 14-fold selectivity against TC-PTP, and this compound was tested in a mouse model for its efficacy to prevent diet-induced obesity. It effectively suppressed the increases in body weight and adipose mass, without any noticeable toxic effect. The compound also prevented increases in the plasma triglyceride, cholesterol, and nonesterified fatty acid concentrations; thus, expanding its therapeutic potential to other related metabolic diseases, such as hyperlipidemia and hypercholesterolemia.
ALKYLATION OF ACTIVE HYDROGEN COMPOUNDS WITH ALLYLIC AND BENZYLIC ALCOHOLS UNDER CoCl2 CATALYSIS. A USEFUL SYNTHESIS OF GRIFOLIN
Marquet, J.,Moreno-Manas, M.
, p. 173 - 176 (2007/10/02)
CoCl2 is a useful catalyst for the condensation of allylic and benzylic alcohols with active hydrogen compounds.Under these neutral conditions orcinol and farnesol react to afford the antibiotic grifolin.
