5279-86-7 Usage
General Description
8-Fluoro-4-Methyl-1H-quinolin-2-one is a chemical compound with the molecular formula C10H7NOF. It is a derivative of quinolinone and is characterized by the presence of a fluorine atom and a methyl group attached to the quinolinone ring. 8-Fluoro-4-Methyl-1H-quinolin-2-one is used in the pharmaceutical industry as a building block for the synthesis of various biologically active molecules, particularly those with potential antifungal, antimicrobial, and anticancer properties. Its unique structure and chemical properties make it a valuable tool for drug discovery and development. Additionally, the presence of the fluorine atom in its structure also makes it a potentially important molecule for use in fluorine-18 radiolabeling for imaging purposes in positron emission tomography (PET) scans.
Check Digit Verification of cas no
The CAS Registry Mumber 5279-86-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,2,7 and 9 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 5279-86:
(6*5)+(5*2)+(4*7)+(3*9)+(2*8)+(1*6)=117
117 % 10 = 7
So 5279-86-7 is a valid CAS Registry Number.
InChI:InChI=1/C17H14N2O3/c1-9-4-3-5-11(6-9)14-12(8-18)16(19)22-13-7-10(2)21-17(20)15(13)14/h3-7,14H,19H2,1-2H3
5279-86-7Relevant articles and documents
On the Knorr synthesis of 6-bromo-4-methylquinolin-2(1H)-one
Wlodarczyk, Nicolas,Simenel, Catherine,Delepierre, Muriel,Barale, Jean-Christophe,Janin, Yves L.
experimental part, p. 934 - 942 (2011/05/05)
In the course of our work on infectious diseases, we were led to prepare 6-bromo-2-chloro-4-methylquinoline as a starting material. Since surprisingly little has been reported in the literature, the two synthetic steps to this compound were investigated. The synthesis involves a condensation between -keto esters and 4-bromoaniline and the cyclization of the resulting anilides into 6-bromoquinolin-2(1H)-one, otherwise known as the Knorr reaction. The 1H NMR monitoring of the first step allowed us to optimize the conditions leading specifically to the anilide without the occurrence of the alternative crotonate. To illustrate the scope of our finding, few additional anilides featuring electron-attracting groups were prepared. The study of their cyclization revealed some unsuspected steric effect governing this second step. Aside from rectifying a few claims in this chemistry, this study led to a three-step preparation of 6-bromo-2-chloro-4-methylquinoline in 48% overall yield from 4-bromoaniline. Georg Thieme Verlag Stuttgart - New York.
