52816-59-8Relevant articles and documents
Rapid one-pot synthesis of antiparasitic quinolines based upon the microwave-assisted coupling-isomerization reaction (MACIR)
Schramm, Oana G.,Oeser, Thomas,Kaiser, Marcel,Brun, Reto,Müller, Thomas J. J.
, p. 359 - 362 (2008/04/01)
2-Substituted quinolines and related derivatives can be rapidly prepared from (hetero)aryl halides and propargyl alcohols in the sense of a one-pot microwave-assisted coupling-isomerization reaction (MACIR). First biological tests against trypanosomes and protozoans have revealed antiparasitic activity in the lower micromolar range. Georg Thieme Verlag Stuttgart.