52819-96-2

Basic information

• Product Name: aflatoxin Q1
• Synonyms: aflatoxin Q1;AFQ1;(3S)-2,3,6aα,9aα-Tetrahydro-3-hydroxy-4-methoxycyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione;(3S,6aR,9aS)-2,3,6a,9a-Tetrahydro-3-hydroxy-4-Methoxycyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione;[3S-(3α,6aα,9aα)]-2,3,6a,9a-Tetrahydro-3-hydroxy-4-Methoxycyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione
• CAS NO: 52819-96-2
• Molecular Formula: C17H12O7
• Molecular Weight: 328.275
• Product Categories: Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Mutagenesis Research Chemicals;Pharmaceuticals
• Mol File: 52819-96-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 589°Cat760mmHg
• Flash Point: 224.5°C
• Appearance: /
• Density: 1.66g/cm³
• Vapor Pressure: 1.02E-14mmHg at 25°C
• Refractive Index: 1.713
• CAS DataBase Reference: aflatoxin Q1(CAS DataBase Reference)
• NIST Chemistry Reference: aflatoxin Q1(52819-96-2)
• EPA Substance Registry System: aflatoxin Q1(52819-96-2)

Safety Data

• RIDADR: 3172
• HazardClass: 6.1(a)
• PackingGroup: I
• Hazardous Substances Data: 52819-96-2(Hazardous Substances Data)

Usage

Description

Aflatoxin Q1 is a metabolite of Aflatoxin B1, which belongs to the class of aflatoxins. It is characterized by the replacement of the hydrogen at the pro-3S position with a hydroxy group in aflatoxin B1. Aflatoxin Q1 is a hepatocarcinogen in many animal models and is likely a human carcinogen as well. It is produced by the predominant forms of cytochrome P450 enzymes, which are responsible for the biotransformation of AFB1.

Uses

1. Used in Toxicology and Carcinogenicity Research:
Aflatoxin Q1 is used as a research compound for studying its toxicological effects and its role as a potential human carcinogen. It helps in understanding the mechanisms of liver cancer development and the impact of dietary aflatoxins on human health.
2. Used as a Biomarker for Exposure and Risk Assessment:
Aflatoxin Q1 is used as a predictive marker for exposure to dietary aflatoxins. It aids in assessing the risk of aflatoxin contamination in the food supply and helps in developing strategies to mitigate the health risks associated with aflatoxin exposure.
3. Used in Analytical Chemistry and Detection Methods:
Aflatoxin Q1 is employed as a reference compound in the development and validation of analytical methods for the detection and quantification of aflatoxins in various food matrices. This helps in ensuring food safety and quality by monitoring and controlling the levels of aflatoxin contamination.
4. Used in Environmental and Agricultural Studies:
Aflatoxin Q1 is utilized in environmental and agricultural research to study the prevalence of aflatoxin-producing fungi in the environment and their impact on crop contamination. This knowledge is crucial for developing effective strategies to reduce aflatoxin contamination in agricultural products and protect public health.

InChI:InChI=1/C17H12O7/c1-21-9-5-10-11(6-2-3-22-17(6)23-10)15-14(9)12-7(18)4-8(19)13(12)16(20)24-15/h2-3,5-7,17-18H,4H2,1H3/t6-,7-,17+/m0/s1

Relevant articles and documents

Synthesis of aflatoxin Q1

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