528594-30-1

Basic information

• Product Name: Phenol, 2-methoxy-4-(2-nitroethyl)- (9CI)
• Synonyms: Phenol, 2-methoxy-4-(2-nitroethyl)- (9CI);2-methoxy-4-(2-nitroethyl)phenol
• CAS NO: 528594-30-1
• Molecular Formula: C₉H₁₁NO₄
• Molecular Weight: 197.18794
• Product Categories: METHOXY
• Mol File: 528594-30-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 160℃
• Boiling Point: 366℃
• Flash Point: 175℃
• Appearance: /
• Density: 1.252
• CAS DataBase Reference: Phenol, 2-methoxy-4-(2-nitroethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-methoxy-4-(2-nitroethyl)- (9CI)(528594-30-1)
• EPA Substance Registry System: Phenol, 2-methoxy-4-(2-nitroethyl)- (9CI)(528594-30-1)

Safety Data

• Hazardous Substances Data: 528594-30-1(Hazardous Substances Data)

Usage

General Description

The chemical "Phenol, 2-methoxy-4-(2-nitroethyl)- (9CI)" is a nitroaromatic compound with the molecular formula C9H11NO5. It is also known by its systematic name 2-methoxy-4-(2-nitroethyl)phenol. This chemical is commonly used as a raw material in the synthesis of various pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of dyes and pigments. Additionally, it has shown potential as an antifungal and antibacterial agent, making it useful in the development of new medical treatments. However, it is important to handle this chemical with caution as it can be hazardous to human health and the environment.

Upstream product

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Relevant articles and documents

TARGETED BIFUNCTIONAL DEGRADERS

The present invention provides, in one aspect, bifunctional compounds that can be used to promote or enhance degradation of certain circulating proteins. In another aspect, the present invention provides bifunctional compounds that can be used to promote or enhance degradation of certain autoantibodies. In certain embodiments, treatment or management of a disease and/or disorder requires degradation, removal, or reduction in concentration of the circulating protein or the autoantibody in the subject. Thus, in certain embodiments, administration of a compound of the invention to the subject removes or reduces the circulation concentration of the circulating protein or the autoantibody, thus treating, ameliorating, or preventing the disease and/or disorder. In certain embodiments, the circulating protein is TNF.

Chromium-Salen Complex/Nitroxyl Radical Cooperative Catalysis: A Combination for Aerobic Intramolecular Dearomative Coupling of Phenols

We describe an aerobic intramolecular dearomative coupling reaction of tethered phenols using a catalytic system consisting of a chromium-salen (Cr-salen) complex combined with a nitroxyl radical. This novel catalytic system enables formation of various spirocyclic dienone products including those unable to be accessed by previously reported methods efficiently under mild reaction conditions.

Reduction method of nitroolefin

Relating to the technical field of organic synthesis, the invention particularly discloses a reduction method of nitroolefin. The method includes: adding a compound 1 into a mixed solvent of alcohol/water in a certain ratio, adding a metal borohydride at 0-50DEG C, and carrying out stirring reaction; concentrating the obtained solution to a constant weight, and adding ethyl acetate and a saturatedammonium chloride solution into the concentrate; separating the liquid to obtain an upper ethyl acetate layer, and conducting drying and concentrating to obtain a reduction product compound 2. The synthesis method provided by the invention is suitable for aromatic rings and straight-chain alkanes, can control dimer impurities at 3.0% or below and the HPLC purity of aliphatic or aromatic nitro compounds at 95.0% or above. The synthesis method provided by the invention has the advantages of cheap raw materials, green and environment-friendly process, economical efficiency and practicability, and is suitable for industrial production.