528597-97-9

Basic information

• Product Name: 6-oxo-5H,11H-benzo[e]pyrido[3,2-b][1,4]diazepine-11-carboxylic acid 2-[2-{(benzyl(propyl)amino)mehtyl}piperidin-1-yl]ethylamide
• Synonyms: 6-oxo-5H,11H-benzo[e]pyrido[3,2-b][1,4]diazepine-11-carboxylic acid 2-[2-{(benzyl(propyl)amino)mehtyl}piperidin-1-yl]ethylamide
• CAS NO: 528597-97-9
• Molecular Weight: 526.682
• Mol File: 528597-97-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-oxo-5H,11H-benzo[e]pyrido[3,2-b][1,4]diazepine-11-carboxylic acid 2-[2-{(benzyl(propyl)amino)mehtyl}piperidin-1-yl]ethylamide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-oxo-5H,11H-benzo[e]pyrido[3,2-b][1,4]diazepine-11-carboxylic acid 2-[2-{(benzyl(propyl)amino)mehtyl}piperidin-1-yl]ethylamide(528597-97-9)
• EPA Substance Registry System: 6-oxo-5H,11H-benzo[e]pyrido[3,2-b][1,4]diazepine-11-carboxylic acid 2-[2-{(benzyl(propyl)amino)mehtyl}piperidin-1-yl]ethylamide(528597-97-9)

Safety Data

• Hazardous Substances Data: 528597-97-9(Hazardous Substances Data)

Upstream product

• 528597-90-2 2-(benzyl-propyl-carbamoyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 528597-92-4 1-cyanomethylpiperidine-2-carboxylic acid benzylpropylamide 
• 885-70-1 5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one 
• 87571-90-2 11-(chlorocarbonyl)-5,11-dihydro-6h-pyrido[2,3-b][1,4]benzodiazepin-6-one 

Relevant articles and documents

A new synthetic route to compounds of the AFDX-type with affinity to muscarinic M2-receptor

[3-(1,3-Dioxo-1,3-dihydroisoindol-2-yl)-propyl]dimethyl-{6-[(1-{2-[(6-oxo-5, 6-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepine-11-carbonyl)amino]ethyl} piperidin-2-yl-methyl)-propylamino]hexyl}ammonium bromide a hybride containing a fragment of the antagonist of muscarinic receptor AFDX-384 and a W84 moiety known as allosteric modulator of antagonist binding, was synthesized in a divergent synthesis starting from pipecolic acid, phthalic anhydride and 3-amino-2-chloropyridine. This new microwave assisted route is very convenient and allows to modify the piperidine ring, the benzodiazepine system, the phthalimide moiety and the chains connecting the ring systems. Yields and reproducibility were satisfying.