52867-93-3

Basic information

• Product Name: 1-(1-broMo-3-chloropropyl)-4-fluorobenzene
• Synonyms: 1-(1-broMo-3-chloropropyl)-4-fluorobenzene
• CAS NO: 52867-93-3
• Molecular Formula: C₉H₉BrClF
• Molecular Weight: 251.5231632
• Mol File: 52867-93-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(1-broMo-3-chloropropyl)-4-fluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-broMo-3-chloropropyl)-4-fluorobenzene(52867-93-3)
• EPA Substance Registry System: 1-(1-broMo-3-chloropropyl)-4-fluorobenzene(52867-93-3)

Safety Data

• Hazardous Substances Data: 52867-93-3(Hazardous Substances Data)

Usage

Structure

A derivative of benzene with a fluorine atom at the 4th position and a 1-bromo-3-chloropropyl group at the 1st position.

Functional groups

Fluorine atom, bromine atom, chlorine atom, and a propyl chain.

Application

Used in organic synthesis and research as a building block for creating more complex chemical structures.

Intermediate

Valuable intermediate in the production of pharmaceuticals, agrochemicals, and other specialty chemicals.

Synthesis

Can be used as a starting material for the synthesis of various fluorinated compounds due to the presence of the fluorine substituent.

Hazard

Potentially hazardous if not handled properly.

Precaution

Should be handled with care to avoid any adverse effects or accidents.

Upstream product

• 31736-75-1 3-chloro-1-(4-fluorophenyl)propan-1-ol 
• 462-06-6 fluorobenzene 
• 347-93-3 3-chloro-4'-fluoropropiophenone 

Downstream Products

• 745817-28-1 1-(4-fluorophenyl)-1-(2,4-dichlorophenoxy)-3-chloropropane 

Relevant articles and documents

Synthesis and in silico evaluation of novel compounds for PET-based investigations of the norepinephrine transporter

Since the norepinephrine transporter (NET) is involved in a variety of diseases, the investigation of underlying dysregulation-mechanisms of the norepinephrine (NE) system is of major interest. Based on the previously described highly potent and selective NET ligand 1-(3-(methylamino)-1-phenylpropyl)-3-phenyl-1,3-dihydro-2H-benzimidaz- ol-2-one (Me@APPI), this paper aims at the development of several fluorinated methylaminebased analogs of this compound. The newly synthesized compounds were computationally evaluated for their interactions with the monoamine transporters and represent reference compounds for PET-based investigation of the NET.

Imidazole analogues of fluoxetine, a novel class of anti-Candida agents

Imidazole analogues of fluoxetine have been obtained by replacing the methylamino terminus of aminopropane chain with the imidazole ring. The newly designed imidazoles showed potent anti-Candida activity, superior to those of miconazole and other antifungal agents of clinical interest. 1-(4-Chlorophenyl)-l-(2,4-dichlorophenoxy)-3-(1H-imidazol-1-yl)propane (16), the most active among test imidazoles, Was about 2-fold more active and as much less cytotoxic than miconazole. High increase of activity was observed with methyl, nitro, fluorine, and chlorine (Cl > F > CH3 > NO2 > CF3).