528853-66-9

Basic information

• Product Name: ethyl 6-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate
• Synonyms: ethyl 6-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate
• CAS NO: 528853-66-9
• Molecular Weight: 385.484
• Mol File: 528853-66-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: ethyl 6-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 6-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate(528853-66-9)
• EPA Substance Registry System: ethyl 6-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate(528853-66-9)

Safety Data

• Hazardous Substances Data: 528853-66-9(Hazardous Substances Data)

Upstream product

• 5717-41-9 ethyl 2-methylbuta-2,3-dienoate 
• 51608-60-7 N-(benzylidene)-p-methylbenzenesulfonamide 
• 51608-60-7 phenyl N-tosyl imine 

Downstream Products

• 1266677-20-6 C₂₂H₂₅NO₃S 
• 1266677-83-1 C₂₈H₂₅NO₅S 

Relevant articles and documents

(R) ENANATIOMER OF APLEXONE

R-aplexone, methods of preparing R-aplexone, or aplexone substantially free of its S-stereoisomer are disclosed. Methods of using R-aplexone or a pharmaceutically acceptable salt or solvate thereof to treat and/or prevent disease are disclosed. Methods of preparing 6-substituted tetrahydropyridine motifs with high enantiomeric excess are also disclosed.

Diversity through a branched reaction pathway: Generation of multicyclic scaffolds and identification of antimigratory agents

A library of 91 heterocyclic compounds composed of 16 distinct scaffolds has been synthesized through a sequence of phosphine-catalyzed ring-forming reactions, Tebbe reactions, Diels-Alder reactions, and, in some cases, hydrolysis. This effort in diversity-oriented synthesis produced a collection of compounds that exhibited high levels of structural variation both in terms of stereochemistry and the range of scaffolds represented. A simple but powerful sequence of reactions thus led to a high-diversity library of relatively modest size with which to explore biologically relevant regions of chemical space. From this library, several molecules were identified that inhibit the migration and invasion of breast cancer cells and may serve as leads for the development of antimetastatic agents.