528884-49-3

Basic information

• Product Name: (2-amino-4-methyl-phenyl)-cyclohexyl-methanone
• Synonyms: (2-amino-4-methyl-phenyl)-cyclohexyl-methanone
• CAS NO: 528884-49-3
• Molecular Weight: 217.311
• Mol File: 528884-49-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2-amino-4-methyl-phenyl)-cyclohexyl-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-amino-4-methyl-phenyl)-cyclohexyl-methanone(528884-49-3)
• EPA Substance Registry System: (2-amino-4-methyl-phenyl)-cyclohexyl-methanone(528884-49-3)

Safety Data

• Hazardous Substances Data: 528884-49-3(Hazardous Substances Data)

Upstream product

• 931-51-1 cyclohexylmagnesiumchloride 
• 26830-96-6 5-methyl-2-cyanoaniline 
• 766-05-2 cyclohexane carbonitrile 
• 108-44-1 1-amino-3-methylbenzene 

Relevant articles and documents

Discovery and characterization of novel, potent, non-peptide parathyroid hormone-1 receptor antagonists

A 1,3,4-benzotriazepine was identified as a suitable lead in our effort toward obtaining a non-peptide parathyroid hormone-1 receptor (PTH1R) antagonist. A process of optimization afforded derivatives displaying nanomolar PTH1R affinity, a representative example of which behaved as a PTH1R antagonist in cell-based cyclic adenosine monophosphate (cAMP) assays, with selectivity over PTH2 receptors.

BENZOTRIAZEPINONE DERIVATIVES

The present invention is concerned with benzotriazepinone derivatives, their intermediates, uses thereof and processes for their production. In particular, the present invention relates to parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrp) receptor ligands, (PTH-1 or PTH/PTHrp receptor ligands). The invention also relates to methods of preparing such ligands and to compounds which are useful as intermediates in such methods.