52900-92-2Relevant articles and documents
Multistep nucleophilic substitution of the halogen atom in 2-halo-2-alkenals
Rulev,Zinchenko,Keiko,Voronkov
, p. 129 - 132 (1996)
ipso-Substitution of the halogen atom in 2-halo-2-alkenals under the action of secondary amines proceeds via three consecutive steps: addition, nucleophilic substitution, and β-elimination (the AdN-SN-E mechanism). The main intermediates arising in the reactions of 2-chloropropenal and 2-chloro-2-butenal with piperidine were detected by NMR spectroscopy. A general scheme of the reaction is proposed.