5291-14-5

Basic information

• Product Name: 1-Azabicyclo[2.2.2]octan-3-one, 2-methyl-
• CAS NO: 5291-14-5
• Molecular Formula: C8H13NO
• Molecular Weight: 139.197
• Mol File: 5291-14-5.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1-Azabicyclo[2.2.2]octan-3-one, 2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Azabicyclo[2.2.2]octan-3-one, 2-methyl-(5291-14-5)
• EPA Substance Registry System: 1-Azabicyclo[2.2.2]octan-3-one, 2-methyl-(5291-14-5)

Safety Data

• Hazardous Substances Data: 5291-14-5(Hazardous Substances Data)

Usage

General Description

1-Azabicyclo[2.2.2]octan-3-one, 2-methyl- is a chemical compound that contains a bicyclic structure with a nitrogen atom. It is commonly referred to as 3-methyl-1-azabicyclo[2.2.2]octan-3-one and is used in the synthesis of pharmaceuticals and organic compounds. 1-Azabicyclo[2.2.2]octan-3-one, 2-methyl- has potential applications in drug development and is known for its ability to modulate neurotransmitters in the central nervous system. It is a versatile building block in organic chemistry and has been studied for its potential medicinal properties. Overall, 1-Azabicyclo[2.2.2]octan-3-one, 2-methyl- is a valuable compound with various potential applications in the fields of medicine and chemistry.

Upstream product

• 3731-38-2 3-Quinuclidinone 
• 624-92-0 Dimethyldisulphide 
• 5291-26-9 2-methylenequinuclidin-3-one 
• 5832-54-2 2-methylene-3-quinuclidinone hydrochloride 

Downstream Products

• 473795-24-3 (3E/Z)-2-methyl-1-azabicyclo[2.2.2]octan-3-one oxime hydrochloride 
• 934752-71-3 (2,4-dimethoxy-benzyl)-(2-methyl-1-aza-bicyclo[2.2.2]oct-3-yl)-amine 
• 478149-39-2 cis-2-methyl-1-azabicyclo[2.2.2]octan-3-amine dihydrochloride 
• 478149-39-2 trans-2-methyl-1-azabicyclo[2.2.2]octan-3-amine dihydrochloride 
• 400856-11-3 2-methyl-1-azabicyclo[2.2.2]octan-3-one oxime 
• 5261-65-4 2-Methylquinuclidine 

Relevant articles and documents

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy.

1H-PYRAZOLE AND 1H-PYRROLE-AZABICYCLIC COMPOUNDS WITH ALFA-7 NACHR ACTIVITY

The invention provides compounds of Formula (I), wherein Azabicyclo is Formula (I, II, III, IV, V, VI, VII); W is Formula (m); where the variables have the definitions discussed herein. These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals to treat a disease or condition in which α7 is known to be involved.

Substituted azabicyclic moieties for the treatment of disease

The invention provides compounds of Formula I: 1wherein m1 is 0 or 1; m2 is 1 or 2; R1 is —H, alkyl, halogenated alkyl, substituted alkyl, cycloalkyl, or phenyl; R2 is —H, alkyl, halogenated alkyl, substituted alkyl, cycloalkyl, or phenyl, provided that when m1 is 1 at least one of R1 and R2 is —H; or a pharmaceutically acceptable salt, pharmaceutical composition, a pure enantiomer or racemic mixture thereof. The invention also provides a method for treating a disease or condition in a mammal, wherein the α7 nicotinic acetylcholine receptor is implicated and for treating diseases where there is a sensory-gating deficit in a mammal comprising administering to a mammal a therapeutically effective amount of a compound of Formula I. These compounds may be in the form of pharmaceutical salts or compositions, and may be in pure enantiomeric form or may be racemic mixtures.