529509-31-7

Basic information

• Product Name: 1-{4[1-(3-Fluoro-benzyl)-1H-indazol-5-ylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl}-pyrrolidin-3-one
• Synonyms: 1-{4[1-(3-Fluoro-benzyl)-1H-indazol-5-ylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl}-pyrrolidin-3-one
• CAS NO: 529509-31-7
• Molecular Weight: 455.494
• Mol File: 529509-31-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-{4[1-(3-Fluoro-benzyl)-1H-indazol-5-ylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl}-pyrrolidin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{4[1-(3-Fluoro-benzyl)-1H-indazol-5-ylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl}-pyrrolidin-3-one(529509-31-7)
• EPA Substance Registry System: 1-{4[1-(3-Fluoro-benzyl)-1H-indazol-5-ylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl}-pyrrolidin-3-one(529509-31-7)

Safety Data

• Hazardous Substances Data: 529509-31-7(Hazardous Substances Data)

Upstream product

• 114615-82-6 tetrapropylammonium perruthennate 
• 529508-87-0 1-{4-[1-(3-Fluoro-benzyl)-1H-indazol-5-ylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl}-(3R)-pyrrolidin-3-ol 

Relevant articles and documents

C-5 Modified indazolylpyrrolotriazines

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.