52957-66-1

Basic information

• Product Name: 6-NITRO-2,3-DIHYDRO-1H-INDEN-5-YLAMINE
• Synonyms: AKOS 91917;6-NITRO-2,3-DIHYDRO-1H-INDEN-5-YLAMINE;6-nitro-5-indanamine
• CAS NO: 52957-66-1
• Molecular Formula: C₉H₁₀N₂O₂
• Molecular Weight: 178.19
• Mol File: 52957-66-1.mol
• Article Data: 14

Chemical Properties

• Melting Point: 126-128°
• Boiling Point: 349.3°C at 760 mmHg
• Flash Point: 165°C
• Appearance: /
• Density: 1.343g/cm³
• Vapor Pressure: 4.75E-05mmHg at 25°C
• Refractive Index: 1.664
• PKA: 0.71±0.20(Predicted)
• CAS DataBase Reference: 6-NITRO-2,3-DIHYDRO-1H-INDEN-5-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-NITRO-2,3-DIHYDRO-1H-INDEN-5-YLAMINE(52957-66-1)
• EPA Substance Registry System: 6-NITRO-2,3-DIHYDRO-1H-INDEN-5-YLAMINE(52957-66-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 52957-66-1(Hazardous Substances Data)

Usage

General Description

6-NITRO-2,3-DIHYDRO-1H-INDEN-5-YLAMINE is a chemical compound with the molecular formula C9H10N2O2. It is a nitro compound that contains a 2,3-dihydro-1H-inden-5-ylamine group. This chemical is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and organic compounds. It has also been studied for its potential applications in the fields of medicinal chemistry and material science. 6-NITRO-2,3-DIHYDRO-1H-INDEN-5-YLAMINE is characterized by its nitro and amine functional groups, which give it unique reactivity and potential biological activity. Overall, this chemical compound has versatile applications in various industries and scientific research.

InChI:InChI=1/C9H10N2O2/c10-8-4-6-2-1-3-7(6)5-9(8)11(12)13/h4-5H,1-3,10H2

Upstream product

• 55491-36-6 5-acetamino-6-nitro-indane 
• 24425-40-9 indan-5-amine 
• 59856-06-3 5-acetamidoindane 
• 81614-65-5 N-(4-nitro-2,3-dihydro-1H-inden-5-yl)acetamide 

Downstream Products

• 52957-65-0 5R,6R-trans-5,6-diaminoindan 
• 81864-39-3 2-mercaptocyclopentano<1,2-f>benzimidazole 
• 75369-86-7 5-Nitro-6-phenoxyindan 
• 82471-98-5 6-Phenyl-5-indanylamin 
• 75370-23-9 6-phenylthio-5-indanylamine 
• 75370-22-8 6-(3-fluorophenoxy)-5-indanylamine 
• 75370-14-8 6-(3-Chloro-phenoxy)-indan-5-ylamine 
• 75370-25-1 6-(4-fluorophenylthio)-5-indanylamine 
• 75370-26-2 6-(4-chlorophenylthio)-5-indanylamine 
• 75370-21-7 6-(4-bromophenoxy)-5-indanylamine 
• 75370-15-9 6-(2-Fluoro-phenoxy)-indan-5-ylamine 
• 75370-13-7 6-(2-Chloro-phenoxy)-indan-5-ylamine 
• 75370-00-2 5-phenylthio-6-nitroindan 
• 75370-12-6 6-(4-Chloro-2-methyl-phenoxy)-indan-5-ylamine 

Relevant articles and documents

-

-

Discovery and optimization of benzotriazine Di-N-oxides targeting replicating and nonreplicating mycobacterium tuberculosis

Compounds bactericidal against both replicating and nonreplicating Mtb may shorten the length of TB treatment regimens by eliminating infections more rapidly. Screening of a panel of antimicrobial and anticancer drug classes that are bioreduced into cytotoxic species revealed that 1,2,4-benzotriazine di-N-oxides (BTOs) are potently bactericidal against replicating and nonreplicating Mtb. Medicinal chemistry optimization, guided by semiempirical molecular orbital calculations, identified a new lead compound (20q) from this series with an MIC of 0.31 μg/mL against H37Rv and a cytotoxicity (CC 50) against Vero cells of 25 μg/mL. 20q also had equivalent potency against a panel of single-drug resistant strains of Mtb and remarkably selective activity for Mtb over a panel of other pathogenic bacterial strains. 20q was also negative in a L5178Y MOLY assay, indicating low potential for genetic toxicity. These data along with measurements of the physiochemical properties and pharmacokinetic profile demonstrate that BTOs have the potential to be developed into a new class of antitubercular drugs.

PURINE DERIVATIVES USEFUL AS HSP90 INHIBITORS

The present application provides substituted purine derivatives and related compounds of the formulas shown. These com ounds are useful as inhibitors of HSP90, and hence in the treatment of related diseases. (Formulae) Z1-Z3, Xa-Xc, X2, X4, Y and R are as defined in the specification.