52986-65-9

Basic information

• Product Name: Benzeneacetonitrile, a-methyl-3-(2-thienylcarbonyl)-
• CAS NO: 52986-65-9
• Molecular Formula: C14H11NOS
• Molecular Weight: 241.313
• Mol File: 52986-65-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzeneacetonitrile, a-methyl-3-(2-thienylcarbonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, a-methyl-3-(2-thienylcarbonyl)-(52986-65-9)
• EPA Substance Registry System: Benzeneacetonitrile, a-methyl-3-(2-thienylcarbonyl)-(52986-65-9)

Safety Data

• Hazardous Substances Data: 52986-65-9(Hazardous Substances Data)

Upstream product

• 188290-36-0 thiophene 
• 52779-73-4 α-hydroxy-α-methyl-m-tolyl thien-2-yl ketone 
• 52779-80-3 α-chloro-α-methyl-m-tolyl thien-2-yl ketone 
• 5537-71-3 2-(3-carboxyphenyl)propanenitrile 
• 42872-29-7 3-(1-cyanoethyl)benzoyl chloride 

Downstream Products

• 52779-89-2 suprofen 

Relevant articles and documents

Decarboxylation with Carbon Monoxide: The Direct Conversion of Carboxylic Acids into Potent Acid Triflate Electrophiles

We report a new strategy for the conversion of carboxylic acids into potent acid triflate electrophiles. The reaction involves oxidative carbonylation of carboxylic acids with I2 in the presence of AgOTf, and is postulated to proceed via acyl hypoiodites that react with CO to form acid triflates. Coupling this chemistry with subsequent trapping with arenes offers a mild, room temperature approach to generate ketones directly from broadly available carboxylic acids without the use of corrosive and reactive Lewis or Bronsted acid additives, and instead from compounds that are readily available, stable, and functional group compatible.

Aroyl-substituted phenylacetic acid derivatives

Compounds of the class of aroyl-substituted phenylacetic acids and corresponding esters, amides and hydroxamic acids, useful as anti-inflammatory agents and certain novel precursors therefor.