530-75-6 Usage
Description
Acetylsalicylsalicylic Acid, commonly known as Acetylsalicylic Acid or Aspirin, is a well-known analgesic and antipyretic drug. It is a white to almost white fine crystalline powder with chemical properties that make it effective in relieving pain and reducing fever. Aspirin is derived from the acetylsalicylic acid molecule, which has been modified to improve its therapeutic properties and reduce side effects.
Uses
Used in Pharmaceutical Industry:
Acetylsalicylsalicylic Acid is used as an analgesic for the relief of mild to moderate pain, such as headaches, muscle aches, and joint pain. It is also used as an antipyretic to reduce fever and inflammation.
Used in Cardiovascular Applications:
Acetylsalicylsalicylic Acid is used as an antiplatelet agent to prevent blood clot formation, which can help in the treatment and prevention of heart attacks, strokes, and other cardiovascular events.
Used in Antithrombotic Applications:
In the medical field, Acetylsalicylsalicylic Acid is used as an antithrombotic agent to inhibit platelet aggregation and reduce the risk of thrombosis, which can lead to life-threatening conditions such as deep vein thrombosis and pulmonary embolism.
Used in Acetylsalicylic Acid Impurity C:
Acetylsalicylsalicylic Acid is used in the production of Acetylsalicylic Acid Impurity C, which is a byproduct in the synthesis of Aspirin. This impurity is important for quality control and safety assessments in the pharmaceutical industry.
Purification Methods
Crystallise the analgesic from dilute AcOH or EtOH (m 161-162o), MeOH (m 165-168o), and *C6H6/EtOH (m 163-165o). Its solubilities in boiling Et2O, *C6H6 and EtOH are 1.4%, 2.2% and 33%, respectively. [Baker et al. J Chem Soc 201 1951, Garrett et al. J Am Pharm Soc 48 684 1959, Beilstein 10 I 41, 10 II 54, 10 IV 165.]
Check Digit Verification of cas no
The CAS Registry Mumber 530-75-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,3 and 0 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 530-75:
(5*5)+(4*3)+(3*0)+(2*7)+(1*5)=56
56 % 10 = 6
So 530-75-6 is a valid CAS Registry Number.
InChI:InChI=1/C16H12O6/c1-10(17)21-14-9-5-3-7-12(14)16(20)22-13-8-4-2-6-11(13)15(18)19/h2-9H,1H3,(H,18,19)/p-1
530-75-6Relevant articles and documents
COMPOSITIONS FOR THE TREATMENT OF DIABETES AND PRE-DIABETES
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Paragraph 0135-0136, (2014/12/09)
The invention relates to the compositions of formula I or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprises a salt of metformin and the methods for treating or preventing metabolic syndrome, prediabetes and diabetes may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of diabetes mellitus, obesity, lipid disorders, hypertriglyceridemia, hyperglycemia, hyperinsulinemia and insulin resistance.
Hydrolysis of acetylsalicylsalicylic acid and salicylsalicylic acid in aqueous solution
Sunada,Iba,Ogawa,Arakawa,Masuyama,Hara,Otsuka
, p. 2158 - 2161 (2007/10/02)
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Solid-state stability of aspirin in the presence of excipients: Kinetic interpretation, modeling, and prediction
Mroso,Li Wan Po,Irwin
, p. 1096 - 1101 (2007/10/02)
Salicylsalicylic acid and acetylsalicylsalicylic acid were identified as decomposition products of aspirin when mixtures of the drug, with magnesium stearate, were stored in the solid state at 60° and 75% relative humidity. The effect of increasing the concentration of magnesium stearate and the addition of other alkali stearates on the rate of decomposition of aspirin were studied. The validity of the theory that pH changes induced by the alkali stearates account for the catalytic effect of the lubricants on the decomposition was tested. The changes observed were modeled and the mechanism involved elucidated. The potential use of the melting points of aspirin mixtures in predicting the stability of the drug in such drug-excipient mixtures is demonstrated.
