53003-18-2

Basic information

• Product Name: 4-CHLORO-5-METHYLISATIN
• Synonyms: 4-CHLORO-5-METHYLISATIN
• CAS NO: 53003-18-2
• Molecular Formula: C₉H₆ClNO₂
• Molecular Weight: 195.6
• Product Categories: Indane/Indanone and Derivatives
• Mol File: 53003-18-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-CHLORO-5-METHYLISATIN(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-5-METHYLISATIN(53003-18-2)
• EPA Substance Registry System: 4-CHLORO-5-METHYLISATIN(53003-18-2)

Safety Data

• Hazardous Substances Data: 53003-18-2(Hazardous Substances Data)

Usage

General Description

4-Chloro-5-methylisatin is a chemical compound that belongs to the isatin class of chemicals. It is a yellow to greenish-yellow crystalline powder that is slightly soluble in water. 4-CHLORO-5-METHYLISATIN is commonly used in organic synthesis and as a building block for the production of various pharmaceuticals, dyes, and natural products. It can also be used as a reagent for the identification and detection of various organic compounds. Additionally, 4-Chloro-5-methylisatin has been studied for its potential biological and pharmacological activities, including its antibacterial and antiviral properties.

Upstream product

• 155184-79-5 N-(3-chloro-4-methyl-phenyl)-2-hydroxyimino-acetamide 
• 7745-89-3 3-chloro-4-methylaniline hydrochloride 
• 95-74-9 3-chloro-p-toluidine 

Downstream Products

• 155184-82-0 2-amino-5-methyl-6-chlorobenzoic acid 
• 53003-14-8 4-chloro-5-methyl-1-morpholin-4-ylmethyl-indole-2,3-dione 
• 342411-56-7 methyl 2-amino-5-methyl-6-chlorobenzoate 
• 450407-84-8 methyl 2-(N-tert-butyloxycarbonyl)amino-5-methyl-6-chlorobenzoate 
• 450407-83-7 2-(N-tert-butyloxycarbonyl)amino-5-methyl-6-chlorobenzoic acid 
• 15068-35-6 2-chloro-3-methylbenzoic acid 

Relevant articles and documents

Synthesis of substituted tryptanthrin via aryl halides and amines as antitumor and anti-MRSA agents

The natural alkaloid, tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), and its analogues are found to exhibit potent antitumor and anti-MRSA activities. An efficient and convenient method has been developed for the synthesis of tryptanthrin D-ring derivatives through the reaction of substituted tryptanthrins and secondary amines in moderate to good yields. Some of the new compounds exhibited antitumor activities against the human tumor cell lines A549, HCT116 and MDA-MB-231, with mean IC50 values at low micromolar levels. In addition, some of the compounds showed excellent anti-MRSA activities and were more effective than vancomycin, with MIC values of 0.31–1.25 μg/mL for Mu50,RN4220, and Newman strains.