53005-05-3

Basic information

• Product Name: 4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID
• Synonyms: 4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID;2,2'-(1,2-Ethenediyl)bis(5-isothiocyanatobenzenesulfonic acid);4,4'-Bis(isothiocyanato)stilbene-2,2'-bissulfonic acid;4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid;4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid;4,4′-Diisotbiocyano-2,2′-stilbenedisulfnic Acid Disodium Salt;Benzenesulfonic acid,2,2'-(1,2-ethenediyl)bis[5-isothiocyanato-;4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid
• CAS NO: 53005-05-3
• Molecular Formula: C16H10N2O6S4
• Molecular Weight: 454.52
• Product Categories: Cross Linking Reagents;Fluorescent Labels & Indicators
• Mol File: 53005-05-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: >400°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.54g/cm³
• CAS DataBase Reference: 4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID(53005-05-3)
• EPA Substance Registry System: 4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID(53005-05-3)

Safety Data

• HazardClass: IRRITANT-HARMFUL
• Hazardous Substances Data: 53005-05-3(Hazardous Substances Data)

Usage

Description

4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID, also known as DIDS, is a stilbene disulfonate compound that exhibits a yellow crystalline solid appearance. It is characterized by its ability to bind covalently and irreversibly to the outer surface of human erythrocyte membranes. DIDS functions as an anion transport inhibitor, particularly effective against Cl– uptake, and has demonstrated anti-ulcerous properties.

Uses

Used in Pharmaceutical Applications:
4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID is used as an ion channel inhibitor, specifically for anion transport. It is particularly effective in inhibiting anion transport in various mammalian cell types, such as GABA and Cl-. This property makes it a valuable tool in the study and treatment of various medical conditions related to ion transport.
Used in Research Applications:
In the field of research, 4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID is used as a specific binding agent to proteins that are not anion transporters. This characteristic allows researchers to study the interactions between DIDS and various proteins, such as CD4 glycoproteins, to better understand their roles in cellular processes.
Used in Anti-ulcerous Applications:
4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID is used as an anti-ulcerous agent due to its ability to inhibit ATP transport into endoplasmic reticulum vesicles. This property makes it a potential candidate for the development of treatments for ulcers and other gastrointestinal disorders.
Used in Chemical Synthesis:
As a yellow crystalline solid, 4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID can be used as a starting material or intermediate in the synthesis of various chemical compounds, particularly those with potential applications in the pharmaceutical and biotechnology industries.

Biochem/physiol Actions

Primary TargetCl- uptake

Relevant articles and documents

Activatable probes and methods for in vivo gene detection

Probes for detecting a target polynucleotide are provided. One aspect provides a molecular beacon probe set wherein the donor molecular beacon comprises a quantum dot and an acceptor molecular beacon comprises at least one reporter. The probes optionally comprise a protein transduction domain, targeting signal, or a combination thereof. Methods for detecting target polynucleotides using the disclosed probes are also provided.