530145-64-3

Basic information

• Product Name: (R)-2-(N-(2-AMino-5-cyanobenzyl)thiophene-2-sulfonaMido)-3-phenylpropyl benzenesulfonate
• Synonyms: (R)-2-(N-(2-AMino-5-cyanobenzyl)thiophene-2-sulfonaMido)-3-phenylpropyl benzenesulfonate
• CAS NO: 530145-64-3
• Molecular Formula: C₂₇H₂₅N₃O₅S₃
• Molecular Weight: 567.6995
• Mol File: 530145-64-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-2-(N-(2-AMino-5-cyanobenzyl)thiophene-2-sulfonaMido)-3-phenylpropyl benzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(N-(2-AMino-5-cyanobenzyl)thiophene-2-sulfonaMido)-3-phenylpropyl benzenesulfonate(530145-64-3)
• EPA Substance Registry System: (R)-2-(N-(2-AMino-5-cyanobenzyl)thiophene-2-sulfonaMido)-3-phenylpropyl benzenesulfonate(530145-64-3)

Safety Data

• Hazardous Substances Data: 530145-64-3(Hazardous Substances Data)

Upstream product

• 530145-72-3 N-[(5-cyano-2-nitrophenyl)methyl]-N-[(1R)-1-(phenylmethyl)-2-[(phenylsulfonyl)oxy]ethyl]-2-thiophenesulfonamide 
• 530145-62-1 (R)-N-(5-cyano-2-nitrobenzyl)-N-(1-hydroxy-3-phenylpropan-2-yl)thiophene-2-sulfonamide 
• 530145-61-0 (R)-3-[[N-(1-hydroxymethyl-2-phenylethyl)amino]methyl]-4-nitrobenzenecarbonitrile 
• 5267-64-1 (R)-2-amino-3-phenylpropanol 
• 90178-82-8 3-formyl-4-nitrobenzonitrile 
• 96631-89-9 trans-5-cyano-β-dimethylamino-2-nitrostyrene 
• 98-09-9 benzenesulfonyl chloride 

Downstream Products

• 195985-38-7 (R)-2,3,4,5-tetrahydro-3-(phenylmethyl)-4-(thien-2-ylsulfonyl)-1H-1,4-benzodiazepine-7-carbonitrile 
• 195987-41-8 BMS-214662 

Relevant articles and documents

Development of a Practical Synthesis of a Farnesyltransferase Inhibitor

The development of a new and practical synthesis for a farnesyltransferase inhibitor 1 is described. The new route started from 2-nitro-5-cyanotoluene (9) and afforded desired 1 in eight chemical transformations. The key step involved formation of sulfonamide 13 from a hindered β-hydroxyamine 12 through an in situ protection of the hydroxyl group by forming TMS ether. Ultimately, this new route was successfully demonstrated to generate >10 kg of API in 29% overall yield.