53039-46-6

Basic information

• Product Name: Benzene, 1-chloro-2-[(4-methoxyphenyl)methyl]-
• CAS NO: 53039-46-6
• Molecular Formula: C14H13ClO
• Molecular Weight: 232.71
• Mol File: 53039-46-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzene, 1-chloro-2-[(4-methoxyphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-chloro-2-[(4-methoxyphenyl)methyl]-(53039-46-6)
• EPA Substance Registry System: Benzene, 1-chloro-2-[(4-methoxyphenyl)methyl]-(53039-46-6)

Safety Data

• Hazardous Substances Data: 53039-46-6(Hazardous Substances Data)

Upstream product

• 696-62-8 para-iodoanisole 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 
• 5720-07-0 4-methoxyphenylboronic acid 
• 17849-38-6 2-Chlorobenzyl alcohol 
• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 33397-21-6 tris(4-methoxyphenyl)bismuth 

Downstream Products

• 54118-74-0 2-chloro-4'-methoxybenzophenone 

Relevant articles and documents

Cobalt-Catalyzed Formation of Functionalized Diarylmethanes from Benzylmesylates and Aryl Halides

A simple cobalt-catalyzed reductive coupling protocol allowing the synthesis of functionalized diarylmethanes from benzyl mesylate is described. The possibility to directly use the benzyl alcohol as a result of a two-step reaction is also presented. This method tolerates a variety of functional groups. A benzyl radical is likely involved. (Figure presented.).

Palladium-Catalysed Cross-Coupling of Benzylammonium Salts with Boronic Acids under Mild Conditions

Herein, we give a full account of the development of the palladium-catalysed cross-coupling of benzylammonium salts with boronic acids. A range of benzylamine-derived quaternary ammonium salts can be coupled with boronic acids under relatively mild conditions. Our optimization has identified ligands that can be used to chemoselectively cross-couple at the ammonium in the presence of chlorides. We demonstrate that intramolecular palladium-catalysed C-H activation is also a viable pathway for the putative benzyl-Pd(II) intermediate obtained upon oxidative addition and have optimised this to obtain fluorene in good yield.

Coupling of arylboronic acids with benzyl halides or mesylates without adding transition metal catalysts

We report herein a transition-metal-free coupling reaction of arylboronic acids with benzyl halides and mesylates for the construction of C(sp2)[sbnd]C(sp3) bonds. A unique feature of this coupling reaction is the formation regioisomers in some cases. Mechanistic studies suggest that this reaction may proceed via an unprecedented Friedel–Crafts-type reaction pathway under base conditions with the assistance of boronic acid moiety.