53039-60-4

Basic information

• Product Name: Benzenamine, 4-[(4-methoxyphenyl)methyl]-N,N-dimethyl-
• CAS NO: 53039-60-4
• Molecular Formula: C16H19NO
• Molecular Weight: 241.333
• Mol File: 53039-60-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenamine, 4-[(4-methoxyphenyl)methyl]-N,N-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-[(4-methoxyphenyl)methyl]-N,N-dimethyl-(53039-60-4)
• EPA Substance Registry System: Benzenamine, 4-[(4-methoxyphenyl)methyl]-N,N-dimethyl-(53039-60-4)

Safety Data

• Hazardous Substances Data: 53039-60-4(Hazardous Substances Data)

Upstream product

• 100-66-3 methoxybenzene 
• 1703-46-4 N,N-dimethyl-4-hydroxymethylaniline 
• 1151-93-5 4-(N,N-dimethylamino)-4'-methoxybenzophenone 
• 5720-07-0 4-methoxyphenylboronic acid 
• 75637-79-5 (4-dimethylamino-benzyl)-trimethyl-ammonium; iodide 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 94207-51-9 (4-(dimethylamino)phenyl)(4-methoxyphenyl)methanol 

Downstream Products

• 54158-97-3 4-(4-N,N-dimethylaminobenzyl)phenol 

Relevant articles and documents

Iridium-Catalysed Reductive Deoxygenation of Ketones with Formic Acid as Traceless Hydride Donor

An iridium-catalysed deoxygenation of ketones and aldehydes is achieved, with formic acid as hydride donor and water as co-solvent. At low catalyst loading, a number of 4-(N,N-disubstituted amino) aryl ketones are readily deoxygenated in excellent yields and chemoselectivity. Numerous functional groups, especially phenolic and alcoholic hydroxyls, secondary amine, carboxylic acid, and alkyl chloride, are well tolerable. Geminally dideuterated alkanes are obtained with up to 90% D incorporation, when DCO2D and D2O are used in place of their hydrogenative counterparts. The activating 4-(N,N-disubstituted amino)aryl groups have been demonstrated to undergo a variety of useful transformations. The deoxygenative deuterations have been used to prepare a deuterated drug molecule Chlorambucil-4,4-d2. (Figure presented.).

Efficient N-heterocyclic carbene nickel pincer complexes catalyzed cross coupling of benzylic ammonium salts with boronic acids

Pyridine-bridged bis-benzimidazolylidene nickel complexes exhibited very high catalytic activity toward cross coupling of inactive (hetero)aryl benzylic ammonium salts with (hetero)aryl and alkenyl boronic acids under mild reaction conditions. Even at 2 mol% catalyst loading, a wide range of substrates for both coupling partners with different steric and electronic properties were well tolerated.

Thermal rearrangement of N-benzylanilinium hexafluoroantimonates

We prepared p-substituted N-benzylanilinium hexafluoroantimonates, known cationic initiators, and examined their thermal reaction. The thermal reaction produced 2- or 4-benzylanilinium salts as the major products, which resulted from the rearrangement of the benzyl group. The reaction proceeded at lower temperature with higher yield when the substituent in the benzyl group was electron donating.