53097-55-5Relevant articles and documents
Enantioselective construction of quaternary stereogenic carbon atoms by the lewis base catalyzed additions of silyl ketene imines to aldehydes
Denmark, Scott E.,Wilson, Tyler W.,Burk, Matthew T.
, p. 9268 - 9279 (2014)
Silyl ketene imines derived from a variety of α-branched nitriles have been developed as highly useful reagents for the construction of quaternary stereogenic centers via the aldol addition reaction. In the presence of SiCl4 and the catalytic a