531-29-3

Basic information

• Product Name: coniferin
• Synonyms: 4-(3-Hydroxy-1-propenyl)-2-methoxyphenyl β-D-glucopyranoside;4-Hydroxy-3-methoxy-1-(γ-hydroxypropenyl)benzene-4-D-glucoside;Abietin;4-(3-Hydroxy-1-propen-1-yl)-2-Methoxyphenyl β-Glucopyranoside;Coniferosid;Coniferoside;Coniferyl alcohol β-D-glucoside
• CAS NO: 531-29-3
• Molecular Formula: C₁₆H₂₂O₈
• Molecular Weight: 342.342
• Product Categories: Metabolites & Intermediates;Carbohydrates & Derivatives;Enzyme substrates
• Mol File: 531-29-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 186°C
• Boiling Point: 397.8°C (rough estimate)
• Flash Point: 332°C
• Appearance: /
• Density: 1.2628 (rough estimate)
• Vapor Pressure: 1.66E-16mmHg at 25°C
• Refractive Index: 1.4430 (estimate)
• Storage Temp.: ?20°C
• PKA: 12.81±0.70(Predicted)
• Water Solubility: 4.975g/L(cold water)
• CAS DataBase Reference: coniferin(CAS DataBase Reference)
• NIST Chemistry Reference: coniferin(531-29-3)
• EPA Substance Registry System: coniferin(531-29-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 531-29-3(Hazardous Substances Data)

Usage

Definition

ChEBI: A monosaccharide derivative that is coniferol attached to a beta-D-glucopyranosyl residue at position 1 via a glycosidic linkage.

InChI:InChI=1/C16H22O8/c1-22-11-7-9(3-2-6-17)4-5-10(11)23-16-15(21)14(20)13(19)12(8-18)24-16/h2-5,7,12-21H,6,8H2,1H3/b3-2+/t12-,13-,14+,15-,16-/m1/s1

Upstream product

• 133-89-1 UDP-glucose 
• 458-35-5 coniferol 

Relevant articles and documents

Anti-inflammatory terpenes from Schefflera rubriflora C. J. Tseng & G. Hoo with their TNF-α and IL-6 inhibitory activities

The 95% ethanol extract and its EtOAc and n-BuOH fractions obtained from the leaves and twigs of Schefflera rubriflora C. J. Tseng & G. Hoo showed significant inhibitory activities (33.6%, 35.7% and 40.6%, respectively) against croton oil-induced ear inflammation in mice. Bioactivity-guided isolation and separation gave eight previously undescribed terpenes or terpene glycosides. Structural elucidation was based on UV, IR, and NMR spectroscopy, MS, experimental and calculated ECD data, and Mosher's method. To identify anti-inflammatory components from the extract, all the compounds were evaluated for tumor necrosis factor-α (TNF-α) and interleukine-6 (IL-6) inhibitory activities. Four undescribed compounds inhibited mRNA expression of TNF-α and IL-6 with IC50 values of 15.3–52.4 μM.