53102-14-0

Basic information

• Product Name: 3-Chloro-2-cyclopenten-1-one
• Synonyms: 3-Chloro-2-cyclopenten-1-one;3-chlorocyclopent-2-en-1-one;3-chlorocyclopent-2-enone
• CAS NO: 53102-14-0
• Molecular Formula: C₅H₅ClO
• Molecular Weight: 116.5456
• Mol File: 53102-14-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 181°Cat760mmHg
• Flash Point: 60.3°C
• Appearance: /
• Density: 1.23g/cm³
• Vapor Pressure: 0.869mmHg at 25°C
• Refractive Index: 1.501
• CAS DataBase Reference: 3-Chloro-2-cyclopenten-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-2-cyclopenten-1-one(53102-14-0)
• EPA Substance Registry System: 3-Chloro-2-cyclopenten-1-one(53102-14-0)

Safety Data

• Hazardous Substances Data: 53102-14-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H5ClO/c6-4-1-2-5(7)3-4/h3H,1-2H2

Upstream product

• 3859-41-4 1,3-cyclopentadione 
• 63480-12-6 4-chloropentanoyl chloride 
• 77707-93-8 2,2,3,5,5-pentachlorocyclopentanone 
• 120-92-3 cyclopentanone 
• 58435-01-1 4-chloro-4-pentenoic acid 
• 343926-42-1 chlorure de chloro-4 pentene 
• 89856-90-6 acetic acid-(3-chloro-cyclopent-2-enyl ester) 

Downstream Products

• 88841-85-4 3-(Phenylseleno)-2-cyclopenten-1-one 
• 114336-39-9 3-benzenesulphonylcyclopent-2-en-1-one 
• 4683-50-5 3-methoxycyclopent-2-enone 
• 1040271-34-8 3-(2-phenyl-aziridin-1-yl)-cyclopent-2-enone 
• 1040271-37-1 3-[2-(4-methoxy-phenyl)-aziridin-1-yl]-cyclopent-2-enone 

Relevant articles and documents

Synthesis of antiproliferative cephalotaxus esters and their evaluation against several human hematopoietic and solid tumor cell lines: Uncovering differential susceptibilities to multidrug resistance

Deoxyharringtonine (2), homoharringtonine (3), homodeoxyharringtonine (4), and anhydroharringtonine (5) are reported to be among the most potent members of the antileukemia alkaloids isolated from the Cephalotaxus genus. Convergent syntheses of these four natural products are described, each involving novel synthetic methods and strategies. These syntheses enabled evaluation of several advanced natural and non-natural compounds against an array of human hematopoietic and solid tumor cells. Potent cytotoxicity was observed in several cell lines previously not challenged with these alkaloids. Variations in the structure of the ester chain within this family of alkaloids confer differing activity profiles against vincristine-resistant HL-60/RV+, signalling new avenues for molecular design of these natural products to combat multi-drug resistance.

AN IMPROVED PREPARATION OF 3-CHLORO-2-CYCLOPENTENONE

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