53138-75-3

Basic information

• Product Name: Acetic acid, cyclohexylidene-, 1,1-dimethylethyl ester
• Synonyms: Cyclohexyliden-essigsaeure-tert-butylester;Acetic acid,cyclohexylidene-,1,1-dimethylethyl ester;tert-butyl cyclohexylideneacetate;tert-butoxycarbonylmethylenecyclohexane
• CAS NO: 53138-75-3
• Molecular Formula: C12H20O2
• Molecular Weight: 196.28600
• Mol File: 53138-75-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Acetic acid, cyclohexylidene-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, cyclohexylidene-, 1,1-dimethylethyl ester(53138-75-3)
• EPA Substance Registry System: Acetic acid, cyclohexylidene-, 1,1-dimethylethyl ester(53138-75-3)

Safety Data

• Hazardous Substances Data: 53138-75-3(Hazardous Substances Data)

Upstream product

• 41108-81-0 tert-butyl (trimethylsilyl)acetate 
• 108-94-1 cyclohexanone 
• 120823-62-3 tert-butyl (trimethylgermyl)acetate 
• 140184-83-4 Triphenylstannanyl-acetic acid tert-butyl ester 
• 98830-88-7 tert-butyl α-(tri-n-butylstannyl)-α-(trimethylsilyl)acetate 
• 1663-39-4 tert-Butyl acrylate 
• 1192-37-6 methylenecyclohexane 
• 86302-43-4 (tert-Butoxycarbonylmethylene)triphenylphosphorane 
• 108-93-0 cyclohexanol 

Relevant articles and documents

Selective Construction of C?C and C=C Bonds by Manganese Catalyzed Coupling of Alcohols with Phosphorus Ylides

Herein, we report the manganese catalyzed coupling of alcohols with phosphorus ylides. The selectivity in the coupling of primary alcohols with phosphorus ylides to form carbon-carbon single (C?C) and carbon-carbon double (C=C) bonds can be controlled by the ligands. In the conversion of more challenging secondary alcohols with phosphorus ylides the selectivity towards the formation of C?C vs. C=C bonds can be controlled by the reaction conditions, namely the amount of base. The scope and limitations of the coupling reactions were thoroughly evaluated by the conversion of 21 alcohols and 15 ylides. Notably, compared to existing methods, which are based on precious metal complexes as catalysts, the present catalytic system is based on earth abundant manganese catalysts. The reaction can also be performed in a sequential one-pot reaction generating the phosphorus ylide in situ followed manganese catalyzed C?C and C=C bond formation. Mechanistic studies suggest that the C?C bond was generated via a borrowing hydrogen pathway and the C=C bond formation followed an acceptorless dehydrogenative coupling pathway. (Figure presented.).

Matrix metalloprotease inhibitors

The present invention relates to compounds of Formula I: STR1 that are matrix metalloprotease inhibitors, pharmaceutical compositions containing them, methods for their use and methods of preparing these compounds.

Synthesis of α-stannyl α,β-unsaturated carboxylic esters

A synthetic method for the preparation of α-stannyl α,β-unsaturated esters is described.The lithium enolate derived from tert-butyl α-(tri-n-butylstannyl)-α-(trimethylsilyl)acetate reacts with aldehydes to give moderate to good yields of α-stannylated products.The method is not applicable to enolizable ketones.