53147-87-8 Usage
Explanation
The compound is composed of 5 carbon atoms, 10 hydrogen atoms, 4 nitrogen atoms, and 1 sulfur atom.
Explanation
It is derived from the parent compound 1,3,4-thiadiazole, which is a five-membered ring containing two nitrogen atoms and one sulfur atom.
Explanation
This name highlights the presence of an amino group at the 2nd position and two methyl groups at the 5th position of the thiadiazole ring.
Explanation
The compound appears as a pale yellow solid at room temperature.
Explanation
It is mainly used as a building block or intermediate in the production of various pharmaceuticals and agrochemicals due to its unique chemical structure.
Explanation
Studies have shown that 1,3,4-Thiadiazol-2-amine, N,N,5-trimethylmay have antiviral and antitumor properties, making it a potential candidate for further research in the development of new drugs.
Explanation
The compound is also utilized in the synthesis of various other organic compounds and materials, showcasing its versatility in chemical reactions.
Derivative
1,3,4-thiadiazole
Physical state
Pale yellow solid
Primary use
Intermediate in the synthesis of pharmaceuticals and agrochemicals
Potential biological and pharmacological activities
Antiviral and antitumor properties
Additional use
Synthesis of other organic compounds and materials
Check Digit Verification of cas no
The CAS Registry Mumber 53147-87-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,1,4 and 7 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 53147-87:
(7*5)+(6*3)+(5*1)+(4*4)+(3*7)+(2*8)+(1*7)=118
118 % 10 = 8
So 53147-87-8 is a valid CAS Registry Number.
53147-87-8Relevant articles and documents
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: Kinetic and X-ray crystallographic studies
Temperini, Claudia,Cecchi, Alessandro,Boyle, Nicholas A.,Scozzafava, Andrea,Cabeza, Jaime Escribano,Wentworth Jr., Paul,Blackburn, G. Michael,Supuran, Claudiu T.
, p. 999 - 1005 (2008)
2-N,N-Dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide was tested for its interaction with the 12 catalytically active mammalian carbonic anhydrase (CA, EC 4.2.1.1) isozymes, CA I-XIV. The compound is a potent inhibitor of CA IV, VII, IX, XII, and XIII (KIs of 0.61-39 nM), a medium potency inhibitor of CA II and VA (KIs of 121-438 nM), and a weak inhibitor against the other isoforms (CA III, VB, VI, and XIV), making it a very interesting candidate for situations in which a strong/selective inhibition of certain isozymes is needed. The crystal structure of the hCA II adduct of this sulfonamide revealed interesting interactions between the inhibitor and the enzyme which are quite different from those observed in the adducts of CA II with the structurally related aliphatic derivatives zonisamide, 2-amino-1,3,4-thiadiazolyl-5-difluoromethanesulfonamide, and 2-dimethylamino-5-[sulfonamido-(aminomethyl)]-1,3,4-thiadiazole reported earlier.
