53159-55-0Relevant articles and documents
Stereocontrolled [11C]Alkylation of N-Terminal Glycine Schiff Bases To Obtain Dipeptides
Filp, Ulrike,Peko?ak, Aleksandra,Poot, Alex J.,Windhorst, Albert D.
supporting information, p. 5592 - 5596 (2017/10/13)
The use of various quaternary ammonium salts as chiral phase-transfer catalysts allowed effective and stereoselective radiochemical [11C]alkylation to obtain functionalized dipeptides. We herein report a broadly applicable procedure for the asymmetric [11C]alkylation of dipeptides to give labeled N-terminal peptides by using different [11C]alkyl halides. Contended stereoselectivities of the reactions were observed by using 11C-labeled alkyl halides, [11C]methyl iodide and [11C]benzyl iodide, and diastereomeric ratios with different specialized catalysts of 95:5 and 90:10 were achieved, respectively. Accordingly, the straightforward synthesis of enantioenriched compounds should play a vital role in peptide-based radiopharmaceutical development and positron emission tomography imaging.
Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases
Chuck, Chi-Pang,Chen, Chao,Ke, Zhihai,Chi-Cheong Wan, David,Chow, Hak-Fun,Wong, Kam-Bo
, p. 1 - 6 (2013/03/13)
Coronaviral infection is associated with up to 5% of respiratory tract diseases. The 3C-like protease (3CLpro) of coronaviruses is required for proteolytic processing of polyproteins and viral replication, and is a promising target for the deve
Polypeptides and methods of preparation
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, (2008/06/13)
There are disclosed active fragments of vasoactive peptides and methods of preparation. The active fragments comprise the following amino acid sequences: (a) X-MET-ALA-VAL-X1 (b) X-MET-ALA-VAL-LYS-X1 (c) X-MET-ALA-VAL-LYS
