5317-32-8Relevant articles and documents
2-PHENYLIMIDAZO[4,5-B]PYRIDIN-7-AMINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY
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Page/Page column 89-90; 91-92; 114, (2018/03/26)
Compound of formula (I′) or (I′′) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of mammalian kinase enzyme activity, including ROR1 tyrosine kinase activity and may be used in the treatment of disorders associated with such activity.
METHOD FOR PRODUCING N-MONOSUBSTITUTED PIPERAZINE
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Paragraph 0067; 0077, (2017/04/20)
PROBLEM TO BE SOLVED: To provide a method for producing N-monosubstituted piperazine selectively with high productivity and high yields. SOLUTION: An electrophilic reagent and an alkali source are added to a solution comprising piperazine, which has been heated at 70-90°C, to make a reaction occur therebetween, so that an addition ratio of the electrophilic reagent to the piperazine is 0.2-0.7 mole and an addition amount rate of the electrophilic reagent exceeds an addition amount rate of the alkali source. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT
PYRIDAZINE DERIVATIVES AND USE THEREOF AS MEDICAMENTS FOR TREATING MICRORNA VIRAL INFECTION
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Paragraph 0046, (2013/06/27)
Disclosed are pyridazine derivatives represented by formula I or pharmaceutically acceptable salts or hydrates thereof, pharmaceutical compositions comprising the compounds, and the use of the compounds in preparing the medicaments for treating and/or preventing diseases or disorders associated with viral infections. The compounds represented by formula I have antiviral activity, especially anti-microRNA viral activity. Symbols in the compounds represented are described in the specification.