532-43-4 Usage
Description
Thiamine nitrate, also known as the mononitrate salt of thiamine, is a water-soluble vitamin and a member of the vitamin B complex. It is formed from one mole of thiamine base and one mole of nitric acid, resulting in an anhydrous crystalline solid with low hygroscopicity. Thiamine nitrate is a stable form of thiamine, making it suitable for pharmaceutical preparations and dietary supplements.
Uses
Used in Pharmaceutical Industry:
Thiamine nitrate is used as a certified pharmaceutical secondary standard for quality control in pharmaceutical laboratories and manufacturing. It provides a convenient and cost-effective alternative to the preparation of in-house working standards.
Used in Food Industry:
Thiamine nitrate is used as a dietary supplement in various food products, such as crackers, egg substitutes, and enriched flour. It is also preferred for the preparation of multivitamins and as a fortification agent in dry blends and dry products, including wheat flour.
Used in Antioxidant Applications:
Thiamine nitrate exhibits antioxidant properties, inhibiting lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro at concentrations ranging from 1 to 100 μM.
Used in Neuroprotection:
Thiamine nitrate has neuroprotective effects, as it reverses predator stress-induced suppression of hippocampal neurogenesis and decreases the latency of step-down from a platform, indicating anxiolytic-like activity in mice.
Used in Reducing Neurodegeneration:
Thiamine nitrate (8.5 mg/100 g food) has been shown to reduce neurodegeneration and increase survival in Slc19a3-/mice, a model of thiamine metabolism dysfunction syndrome-2 (THMD-2).
References
[1] Food and Agriculture Organization of the United Nations, Food Fortification: Technology and Quality Control: Report of an FAO technical meeting Rome, 1995
[2] Ronald R. Eitenmiller, W. O. Landen Jr and Lin Ye, Vitamin Analysis for the Health and Food Sciences, Second Edition, 2008
[3] Thomas J. Macek, Beate A. Feller and Edward J. Hanus, Pharmaceutical studies with thiamine mononitrate, Journal of Pharmaceutical Sciences, 1950, vol. 39, 365-369
Safety Profile
Poison by intravenous
and intraperitoneal routes. A powerful
oxidizer. When heated to decomposition it emits very toxic fums of SOx, and NOx. See also NITRATES.
Check Digit Verification of cas no
The CAS Registry Mumber 532-43-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,3 and 2 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 532-43:
(5*5)+(4*3)+(3*2)+(2*4)+(1*3)=54
54 % 10 = 4
So 532-43-4 is a valid CAS Registry Number.
InChI:InChI=1/C12H17N4OS.NO3/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;2-1(3)4/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);/q+1;-1
532-43-4Relevant articles and documents
Thiamin Acetate, C12H17N4OS+.C2H3O2-
Casas, Jose S.,Castineiras, Alfonso,Couce, Maria D.,Sordo, Jose,Varela, Jose M.
, p. 1265 - 1267 (1994)
In thiamin acetate crystals, the thiamin cation -5-(2-hydroxyethyl)-4-methylthiazolium> adopts the usual F conformation, with torsion angles C5'-C3,5'-N3-C2 and N3-C3,5-C5'-C4' (between the pyridinyl and thiazolium moieties) of 5.6(7) and -83.5(6) deg, respectively.Hydrogen bonds involving the O5γ-H hydroxyl and N4α'-H2 amine groups and the N1' and N3' pyrimidine atoms interconnect the thiamin cations.The acetate anions are hydrogen bonded to the N4α'-H2 group and probably also to the C2-H group of the thiazole ring.
A nitric-acid thiamine new synthesis mode (by machine translation)
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Paragraph 0015; 0016; 0017; 0018, (2018/05/01)
The invention discloses a method for nitric acid thiamine new synthesis mode, characterized in that the sulfur on behalf of the thiamine by hydrogen peroxide oxidation of oxidizing liquid, rotation of calcium salt, to obtain calcium sulphate solids separation, then the use of ammonia and in [...], get the nitric acid thiamine, after separation, in the mother liquor contains only ammonium sulfate, through three-effect evaporation to obtain pure ammonium sulfate. The invention disclosed nitric acid thiamine new synthetic way improves the traditional view of converting the ammonium nitrate, calcium transfer salt, not only in the yield and quality has not been affected, but also for later mother liquor and processing has the great advantage of, there is a by-product calcium sulfate generation, there is a pure ammonium sulfate generation, can solve the traditional process the mother liquor in the thiamine nitrate high ammonia nitrogen situation. (by machine translation)
