53209-37-3Relevant articles and documents
Synthesis, in vitro and in vivo evaluation of 2-aryl-4H-chromene and 3-aryl-1H-benzo[f]chromene derivatives as novel α-glucosidase inhibitors
Spasov, Alexander A.,Babkov, Denis A.,Osipov, Dmitry V.,Klochkov, Vladlen G.,Prilepskaya, Diana R.,Demidov, Maxim R.,Osyanin, Vitaly A.,Klimochkin, Yuri N.
supporting information, p. 119 - 123 (2018/10/20)
Herein we report a study of novel arylchromene derivatives as analogs of naturally occurring flavonoids with prominent α-glucosidase inhibitory properties. Novel inhibitors were identified via simple stepwise in silico screening, efficient synthesis, and biological evaluation. It is shown that 2-aryl-4H-chromene core retains pharmacophore properties while being readily available synthetically. A lead compound identified through screening inhibits yeast α-glucosidase with IC50 of 62.26 μM and prevents postprandial hyperglycemia in rats at 2.2 mg/kg dose.
Synthesis of 2,4-Diaryl-4H-Chromenes via Decarboxylative Alkylation of β-Keto Acids to ortho-Quinone Methides as Reactive Intermediates
Kim, Joo Hee,Kim, Dae Young
, p. 1007 - 1010 (2018/08/01)
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TFA-mediated tandem Friedel-Crafts alkylation/cyclization/hydrogen transfer process for the synthesis of flavylium compounds
Wu, Yan-Chao,Liu, Li,Liu, Yu-Liang,Wang, Dong,Chen, Yong-Jun
, p. 9383 - 9386 (2008/03/13)
(Chemical Equation Presented) The tandem reaction of phenols and chalcones in refluxing TFA gave the flavylium species of 2-hydroxy-2-phenyl-2H-chromenes in moderate to good isolated yields. The reaction was proposed to involve a tandem transformation of
