53249-34-6Relevant articles and documents
Cefprozil refining method
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Paragraph 0027-0029; 0034-0036; 0041-0043, (2019/12/02)
The invention discloses a cefprozil refining method. The method includes: (1) dissolving a crude cefprozil product in a mixed solvent of deionized water, ethanol and dichloromethane, conducting heating reflux dissolution to prepare a saturated or supersaturated solution; (2) performing cooling to 20-30DEG C, adding activated carbon for decolorization, conducting filtration, cooling the filtrate to5DEG C-10DEG C, performing crystallization for 1h, conducting cooling to 0DEG C-5DEG C, and performing crystal growing; (3) conducting filtering, and performing leaching with ethanol to obtain a white solid; and (4) placing the white solid obtained by step (3) in a vacuum drying box, conducting vacuum pumping, and performing drying for 3h or more, thus obtaining cefprozil crystals. The refining method provided by the invention remarkably improves the product quality, and is simple in operation, thus being suitable for industrial production.
Method of preparing cephalosporins using 4-hydroxyphenylglycine derivatives
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, (2008/06/13)
High purity cephalosporin compound can be easily prepared in a high yield by a process comprising the steps of: reacting a cephem compound with a 4-hydroxyphenylglycine derivative.
A NOVEL SYNTHESIS OF (+/-)-3-AMINONOCARDICINIC ACID
Chiba, K.,Mori, M.,Ban, Y.
, p. 387 - 392 (2007/10/02)
(+/-)-3-Aminonocardicinic acid (3-ANA, 2), which is an important material for the synthesis of nocardicin A (1) and other biologically active analogues, has been synthesized by the application of a new method for the synthesis of α-methylene-β-lactams.