5325-64-4

Basic information

• Product Name: N-ALPHA-METHYL-L-ALANINE HYDROCHLORIDE
• Synonyms: SAR-NH2 HCL;SARCOSINE-NH2 HCL;SARCOSINE AMIDE HYDROCHLORIDE;SARCOSINAMIDE HYDROCHLORIDE;N-ME-ALA-OH HCL;N-ME-GLY-NH2 HCL;N-METHYL-L-ALANINE HYDROCHLORIDE;N-METHYL-GLYCINE AMIDE HYDROCHLORIDE
• CAS NO: 5325-64-4
• Molecular Formula: C₃H₈N₂O*ClH
• Molecular Weight: 124.57
• EINECS: 1533716-785-6
• Product Categories: Unusual Amino Acids
• Mol File: 5325-64-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 160-162 °C
• Appearance: Off white to pale yellow/Solid
• Storage Temp.: −20°C
• CAS DataBase Reference: N-ALPHA-METHYL-L-ALANINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ALPHA-METHYL-L-ALANINE HYDROCHLORIDE(5325-64-4)
• EPA Substance Registry System: N-ALPHA-METHYL-L-ALANINE HYDROCHLORIDE(5325-64-4)

Safety Data

• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 5325-64-4(Hazardous Substances Data)

Usage

General Description

N-ALPHA-METHYL-L-ALANINE HYDROCHLORIDE is a synthetic compound that contains an amino acid derivative called alpha-methylalanine, which is commonly used as a building block in the synthesis of peptides and other bioactive compounds. The hydrochloride salt form of this chemical is often used for pharmaceutical purposes, as it can enhance the solubility and stability of the compound in aqueous solutions. N-ALPHA-METHYL-L-ALANINE HYDROCHLORIDE has been studied for its potential use in drug development and research, particularly in the field of neuroscience and neuropharmacology, due to its ability to modulate certain neurotransmitter systems in the brain.

Upstream product

• 79-07-2 Chloroacetamide 
• 74-89-5 methylamine 

Downstream Products

• 106231-62-3 Benzoic acid (carbamoylmethyl-methyl-carbamoyl)-methyl ester 
• 111184-56-6 3-methyl-5-phenylhydantoinamide 

Relevant articles and documents

Synthesis method of 3-aminopyrrole-2-formamide compound

The invention discloses a synthesis method of a 3-aminopyrrole-2-formamide compound. The synthesis method comprises the following steps of: 1) a compound is prepared by using ammonia or alkylamine R1NH2 and chloroacetamide as raw materials and water as a solvent under the condition of ice bath; 2) under the condition of ice bath, the compound and another compound are used as raw materials and react in the solvent under the action of sodium acetate to prepare a compound; and 3) the compound is used as the raw material and subjected to a ring closing reaction in the solvent under the action of alkali, and the target compound is obtained. The method has the advantages of short synthesis route, mild reaction conditions, few side reactions, simple post-treatment method, high yield and low cost,and is suitable for large-scale industrial production.

Prodrug derivatives of carboxylic acid drugs

Novel ester derivatives of carboxylic acid medicaments of formula (I), wherein R--COO--represents the acyloxy residue of a carboxylic acid drug or medicament, n is an integrer from 1 to 3, and R1 and R2 are the same or different and are selected from a group consisting of an alkyl, an alkenyl, an aryl, an aralkyl, a cycloalkyl and which group may be unsubstituted or substituted, or R1 and R2 together with the N forms a 4-, 5-, 6- or 7-membered heterocyclic ring, which in addition to the nitrogen atom may contain one or two further heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur and which heterocyclic group may be substituted. These compounds are highly biolabile prodrug forms of the corresponding carboxylic acid compounds and are highly susceptible to undergoing enzymatic hydrolysis in vivo whereas they are highly stable in aqueous solution. The novel derivatives are less irritating to mucosa than the parent carboxylic acids and may provide an improved bio-availability of the drugs.