53267-93-9

Basic information

• Product Name: Boc-O-methyl-L-tyrosine
• Synonyms: BOC-O-METHYL-L-TYROSINE;BOC-PHE(4-OME)-OH;BOC-P-METHOXY-PHE-OH;BOC-L-TYR(ME);BOC-L-TYR(ME)-OH;BOC-L-4-METHOXYPHE;BOC-4-METHOXYPHENYLALANINE;BOC-4-METHOXY-PHE-OH
• CAS NO: 53267-93-9
• Molecular Formula: C₁₅H₂₁NO₅
• Molecular Weight: 295.33
• Product Categories: Phenylalanine [Phe, F];Unusual Amino Acids;Boc-Amino Acids and Derivative;Boc-Amino acid series
• Mol File: 53267-93-9.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 462 °C at 760 mmHg
• Flash Point: 233.2 °C
• Appearance: /Solid
• Density: 1.168 g/cm³
• Vapor Pressure: 2.47E-09mmHg at 25°C
• Refractive Index: 1.522
• Storage Temp.: Store at 0-5°C
• PKA: 3.00±0.10(Predicted)
• CAS DataBase Reference: Boc-O-methyl-L-tyrosine(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-O-methyl-L-tyrosine(53267-93-9)
• EPA Substance Registry System: Boc-O-methyl-L-tyrosine(53267-93-9)

Safety Data

• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 53267-93-9(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

Boc-Tyr(Me)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

InChI:InChI=1/C15H21NO5/c1-15(2,3)21-14(19)16-12(13(17)18)9-10-5-7-11(20-4)8-6-10/h5-8,12H,9H2,1-4H3,(H,16,19)(H,17,18)/t12-/m0/s1

Upstream product

• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 6230-11-1 O-Methyltyrosine 
• 67423-44-3 (S)-2-amino-3-(4-methoxyphenyl)propanoic acid hydrochloride 
• 94790-24-6 (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-methoxyphenyl)propanoate 
• 3978-80-1 Boc-Tyr-OH 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 3417-91-2 L-tyrosine methyl ester HCl 
• 60-18-4 L-tyrosine 
• 35448-10-3 oxalic acid mono-tert-butyl ester 
• 17355-19-0 methyl (S)-2-amino-3-(4-methoxyphenyl)propionate 

Downstream Products

• 7479-01-8 O-methyl-L-tyrosine methyl ester hydrochloride 
• 142410-17-1 1-(2,3-dideoxy-3-(N-t-butyloxycarbonyl-p-methoxy-L-phenylalanylamino)-α-D-erythro-pentofuranosyl)thymine 
• 94790-23-5 Boc-(OCH₃)-Tyr-D-Ala-Gly-Phe-Leu-OBzl 
• 126686-66-6 Z-Thr--CAM 
• 80361-99-5 6-(dimethylamino)-9-<3'-<amino>-5'-chloro-3',5'-dideoxy-β-D-ribofuranosyl>purine 
• 142410-13-7 1-(2,3-dideoxy-3-(N-t-butyloxycarbonyl-p-methoxy-L-phenylalanylamino)-β-L-erythro-pentofuranosyl)thymine 
• 142410-15-9 1-(2,3-dideoxy-3-(N-t-butyloxycarbonyl-p-methoxy-L-phenylalanylamino)-α-L-erythro-pentofuranosyl)thymine 
• 108868-76-4 [(S)-1-[(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(4-methyl-pentanoylamino)-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-(4-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 110205-97-5 [(S)-1-[(S)-1-[(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-(propane-2-sulfonyl)-propylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-(4-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 142410-19-3 1-(2,3-dideoxy-3-(N-t-butyloxycarbonyl-p-methoxy-L-phenylalanylamino)-β-D-erythro-pentofuranosyl)thymine 
• 122900-19-0 N^α-tert-butyloxycarbonyl-O-methyl-(S)-tyrosine methylamide 
• 142995-38-8 Boc-Phe(4-OMe)-NMeBzl 
• 126395-29-7 [(S)-2-hydroxy-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester 
• 167316-06-5 N--O⁴-methyl-L-tyrosyl>-L-alanine methyl ester 

Relevant articles and documents

INHIBITOR OF APOPTOSIS (IAP) PROTEIN ANTAGONISTS

Provided herein are compounds that modulate the activity of melanoma inhibitor of apoptosis (ML-IAP) protein, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

Design, synthesis and preliminary bioactivity studies of indomethacin derivatives as Bcl-2/Mcl-1 dual inhibitors

Bcl-2 family proteins, which divides into pro-apoptosis proteins and anti-apoptosis proteins, are involved in cell apoptosis progression. As numerous studies illustrated, targeting Bcl-2 family proteins is more and more attractive and practicable to cancer treatment. In this work, we designed and synthesized a series of indomethacin derivatives as new inhibitors for Bcl-2 family proteins. Our results of binding assay to Bcl-2 proteins, MTT assay and apoptotic assay indicated that some compounds had potent binding affinity to Bcl-2/Mcl-1 but not Bcl-XL. Furthermore, compound 8j showed improved anti-proliferative activity than known Bcl-2 inhibitor WL-276.

Preparation method of O-methyl-threonine/tyrosine

The invention relates to a preparation method of O-methyl-threonine/tyrosine. The preparation method mainly overcomes the disadvantages of the existing method that a toxic reagent is volatile, the reagent is dangerous, the steps are long, the yield is low, and the like. The preparation method of the O-methyl-threonine/tyrosine comprises the following steps: N-t-butyloxycarboryl-threonine/tyrosineis catalyzed by sodium hydroxide and reacts with dimethyl sulfate to generate N-t-butyloxycarboryl-O-methyl-threonine/tyrosine, and then t-butyloxycarboryl is removed from the N-t-butyloxycarboryl-O-methyl-threonine/tyrosine through acid substances to obtain the product O-methyl-threonine/tyrosine. The product has important application in the fields of antibiotics and polypeptide drugs.