5327-22-0 Usage
General Description
Pyrrolidine-1-carboxylic acid isopropyl ester, also known as proline isopropyl ester, is a chemical compound derived from the amino acid proline. It is commonly used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of flavor and fragrance compounds. Pyrrolidine-1-carboxylic acid isopropyl ester is a colorless liquid with a faint odor and is considered to be relatively stable under normal conditions. Proline isopropyl ester is also known for its low toxicity and is generally considered to be safe for handling and use when appropriate precautions are taken. Overall, this chemical serves as a valuable building block in the synthesis of various products in the pharmaceutical and chemical industries.
Check Digit Verification of cas no
The CAS Registry Mumber 5327-22-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,2 and 7 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 5327-22:
(6*5)+(5*3)+(4*2)+(3*7)+(2*2)+(1*2)=80
80 % 10 = 0
So 5327-22-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H15NO2/c1-7(2)11-8(10)9-5-3-4-6-9/h7H,3-6H2,1-2H3
5327-22-0Relevant articles and documents
Selective Ring-Opening of N-Alkyl Pyrrolidines with Chloroformates to 4-Chlorobutyl Carbamates
Yu, Chunghyeon,Shoaib, Mahbubul Alam,Iqbal, Naeem,Kim, Jun Soo,Ha, Hyun-Joon,Cho, Eun Jin
, p. 6615 - 6620 (2017/07/15)
Our study shows that among aza-heterocycles of various ring sizes, including aziridines, azetidines, pyrrolidines, and piperidines, only N-alkyl pyrrolidines undergo competitive reaction pathways with chloroformates to yield N-dealkylated pyrrolidines and 4-chlorobutyl carbamates. The pathway taken depends on the substituent on the nitrogen, i.e., ring-opening with methyl and ethyl substituents and dealkylation with a benzyl substituent. Computational calculations support the substituent-dependent product formation by showing the energy difference between the transition states of both reaction pathways. Selective ring-opening reactions of N-methyl and N-ethyl pyrrolidine derivatives with chloroformates were utilized to prepare various 4-chlorobutyl carbamate derivatives as valuable 1,4-bifunctional compounds.
