53297-75-9

Basic information

• Product Name: N-(2-chlorocyclohexyl)acetamide
• CAS NO: 53297-75-9
• Molecular Formula: C₈H₁₄ClNO
• Molecular Weight: 175.6559
• Mol File: 53297-75-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 346.2°C at 760 mmHg
• Flash Point: 163.2°C
• Density: 1.09g/cm³
• Vapor Pressure: 5.85E-05mmHg at 25°C
• Refractive Index: 1.481
• CAS DataBase Reference: N-(2-chlorocyclohexyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-chlorocyclohexyl)acetamide(53297-75-9)
• EPA Substance Registry System: N-(2-chlorocyclohexyl)acetamide(53297-75-9)

Safety Data

• Hazardous Substances Data: 53297-75-9(Hazardous Substances Data)

Upstream product

• 55005-83-9 2-chloro-cyclohexylamine 
• 75-36-5 acetyl chloride 
• 598-49-2 N-chloroacetamide 
• 110-83-8 cyclohexene 
• 77037-14-0 trans 2-acetamido-1-phenylselenocyclohexane 
• 67-56-1 methanol 
• 71-43-2 benzene 
• 75-05-8 acetonitrile 
• 108-24-7 acetic anhydride 
• 21113-05-3 1-chloromercuri-2-acetamidocyclohexane 
• 35070-77-0 N-chloro-alpha-chloroacetamide 
• 5014-39-1 N-chloro-N-methylacetamide 
• 473-34-7 N,N-dichloro-p-toluenesulfonamide 

Downstream Products

• 38898-70-3 cis-2-amino-cyclohexanol-⁽¹⁾ 

Relevant articles and documents

Lewis basic selenium catalyzed chloroamidation of olefins using nitriles as the nucleophiles

A Lewis base catalyzed chloroamidation of olefinic substrates was achieved using diphenyl selenide as the catalyst. The reaction conditions are mild and suitable for a wide range of substrates including those which are acid labile.

New method for chloroamidation of olefins. Application in the synthesis of N-glycopeptides and anticancer agents

(Chemical Equation Presented) Chloroamidation of olefins using a new reagent system (COCl)2-AgNO3-CH3CN was observed. Various glycals with this reagent system produce 2-chloro-1-acetamido sugars in good yields which, in turn, were converted to free amino derivatives and various glycopeptides. The acetamido sugar derivatives and free amines were found to be promising anticancer agents against the U-87 malignant glyoma (a brain tumor) cell line with IC-50 = 1 nm-22 μM, and they were found to be far less cytotoxic against a normal human embryonic kidney cell line.

Addition reactions of nitryl chloride at multiple bonds

Published data on additio of nitryl chloride to alkenes and possible reaction mechanisms were analyzed. Reactions of nitryl chloride with alkenes differing in the ionization potentials of the double bond and in the abilities to undergo various structural rearrangements were studied. Nitryl chloride was shown to be very sensitive both to the substrate and to the reaction conditions.