53308-83-1 Usage
Description
Ng-monomethyl-l-arginine acetate (L-NMMA) is a white crystalline powder that serves as a competitive nitric oxide synthase (NOS) inhibitor. It is considered the archetypal NOS inhibitor, and its effectiveness is often compared to other inhibitors in the field. L-NMMA is a relatively non-selective inhibitor, affecting all NOS isoforms with Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) being approximately 0.18, 0.4, and 6 μM, respectively.
Uses
Used in Biological Research:
Ng-monomethyl-l-arginine acetate is used as a reagent to inhibit nitric oxide production in biological systems. This application is crucial for studying the role of nitric oxide in various physiological processes and its involvement in diseases.
Used as a Nitric Oxide Synthase Inhibitor:
In the pharmaceutical and medical fields, L-NMMA is used as a nitric oxide synthase inhibitor. Its ability to inhibit all NOS isoforms makes it a valuable tool for understanding the functions of nitric oxide in the body and for developing targeted therapies for conditions where nitric oxide production is a factor.
Used in Drug Development:
Ng-monomethyl-l-arginine acetate can be utilized in the development of new drugs that target nitric oxide synthase, potentially leading to treatments for a variety of conditions related to nitric oxide dysregulation.
Used in Anticancer Applications:
While not explicitly mentioned in the provided materials, given its role as a NOS inhibitor, L-NMMA could potentially be investigated for its use in cancer research and treatment, as nitric oxide has been implicated in tumor growth and progression.
Used in Drug Delivery Systems:
Similar to gallotannin, L-NMMA could be incorporated into drug delivery systems to improve its bioavailability and therapeutic outcomes. This application would require further research and development to optimize the delivery method and ensure the desired effects are achieved.
Biological Activity
Competitive, irreversible inhibitor of all three NOS isoforms.
Biochem/physiol Actions
NG-Methyl-L-arginine is an inhibitor of nitric oxide synthase in neurons, endothelial cells, and macrophages. It inhibits endothelium-derived relaxing factor and promotes contraction in pulmonary artery and vein. It stereo selectively inhibits the generation of nitric oxide (NO) from arginine. It promotes epinephrine and glucose levels, contributing to hyperglycemia in central nervous system.
Check Digit Verification of cas no
The CAS Registry Mumber 53308-83-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,3,0 and 8 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 53308-83:
(7*5)+(6*3)+(5*3)+(4*0)+(3*8)+(2*8)+(1*3)=111
111 % 10 = 1
So 53308-83-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H16N4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11)/p+1/t5-/m0/s1
