53314-95-7 Usage
General Description
7-Fluoro-DL-tryptophan is a chemical compound that is a derivative of the amino acid tryptophan. It is a non-natural amino acid that contains a fluorine atom at the 7th position. 7-FLUORO-DL-TRYPTOPHAN is often used in research and pharmaceutical applications as a precursor for the synthesis of novel drugs and biologically active molecules. Its unique structure and properties make it a valuable tool for studying the role of tryptophan in biochemical processes and as a potential therapeutic target for various conditions. Additionally, this compound has potential applications in the development of new antibiotics, anti-cancer drugs, and other pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 53314-95-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,3,1 and 4 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 53314-95:
(7*5)+(6*3)+(5*3)+(4*1)+(3*4)+(2*9)+(1*5)=107
107 % 10 = 7
So 53314-95-7 is a valid CAS Registry Number.
53314-95-7Relevant articles and documents
Structure-activity relationship study of novel necroptosis inhibitors
Teng, Xin,Degterev, Alexei,Jagtap, Prakash,Xing, Xuechao,Choi, Sungwoon,Denu, Regine,Yuan, Junying,Cuny, Gregory D.
, p. 5039 - 5044 (2007/10/03)
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-α. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins). A SAR study revealed that several positions of the indole were intolerant of substitution, while small substituents at the 7-position resulted in increased inhibitory activity. The hydantoin ring was also quite sensitive to structural modifications. A representative member of this compound class demonstrated moderate pharmacokinetic characteristics and readily entered the central nervous system upon intravenous administration.
