5333-02-8

Basic information

• Product Name: 5,6-dimethoxy-8-nitroquinoline
• Synonyms: 5,6-Dimethoxy-8-nitroquinoline; 5,6-Dimethoxy-8-nitro-quinoline
• CAS NO: 5333-02-8
• Molecular Formula: C₁₁H₁₀N₂O₄
• Molecular Weight: 234.2081
• Mol File: 5333-02-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 410.2°C at 760 mmHg
• Flash Point: 201.9°C
• Density: 1.326g/cm³
• Vapor Pressure: 1.46E-06mmHg at 25°C
• Refractive Index: 1.62
• CAS DataBase Reference: 5,6-dimethoxy-8-nitroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-dimethoxy-8-nitroquinoline(5333-02-8)
• EPA Substance Registry System: 5,6-dimethoxy-8-nitroquinoline(5333-02-8)

Safety Data

• Hazardous Substances Data: 5333-02-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 64992-86-5 5-chloro-6-methoxy-8-nitro-quinoline 
• 124-41-4 sodium methylate 
• 5347-15-9 5-bromo-6-methoxy-8-nitroquinoline 
• 7595-31-5 4-amino-5-nitroveratrol 
• 56-81-5 glycerol 
• 99069-17-7 4-Acetylamino-1,2-dimethoxy-5-nitrobenzene 
• 107-02-8 acrolein 
• 91-16-7 1,2-dimethoxybenzene 
• 85-81-4 6-methoxy-8-nitroquinoline 
• 3395-03-7 4,5-dimethoxy-1,2-dinitrobenzene 

Downstream Products

• 6938-02-9 8-amino-5,6-dimethoxyquinoline 
• 685092-60-8 2-cyclohexyl-5,6-dimethoxy-8-nitroquinoline 
• 685092-69-7 2-cyclohexyl-5,6-dimethoxy-8-quinolinamine 
• 685092-78-8 2-[4-(2-cyclohexyl-5,6-dimethoxy-8-quinolinamino)pentyl]-1,3-isoindolinedione 
• 861232-19-1 2-tert-butyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolinamine 
• 861232-16-8 2-tert-butyl-6-methoxy-8-nitro-5-(3-trifluoromethylphenoxy)quinoline 
• 861232-22-6 2-{4-[2-tert-butyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolylamino]pentyl}-1,3-isoindolinedione 
• 17605-76-4 8-(5-isopropylamino-pentylamino)-quinoline-5,6-diol 
• 87321-06-0 5-hydroxy-6-desmethylprimaquine 

Relevant articles and documents

Metal-free synthesis of N-fused heterocyclic iodides via C-H functionalization mediated by tert-butylhydroperoxide

Direct, regioselective and metal-free synthesis of fused N-heterocyclic iodides is reported. This regioselective C-H functionalization is mediated by tert-butylhydroperoxide (TBHP), via dual activation of molecular iodine and a heterocyclic substrate, resulting in the in situ generation of electrophilic iodine species (I+), and free radical(s) tBuO? or tBuOO?, driving the iodination reaction.

8-Aminoquinolines as anticoccidials - I

The proposed ring metabolites of the 8-aminoquinoline antimalarial, pentaquine, 1, have been synthesised and their biological activity as anticoccidial agents investigated in vivo. Several analogues in which this metabolic pathway had been blocked were also synthesised and their anticoccidial activity measured.

Process for production of 8-NHR quinolines

An improved process for producing 8-NHR quinolines from 8-aminoquinolines disclosed. The process comprises reacting 8-aminoquinolines with a substituted alkyl halide in the presence of an amine having a boiling point of 80°-90° C. The amine functions as an acid acceptor whereby the amine salt formed may be efficiently separated from the 8-NHR quinoline formed without expensive or time consuming purification steps. The reaction may be carried out in the presence of a solvent such as an alcohol.