5334-28-1

Basic information

• Product Name: 5-AMINO-1-(4-BROMOPHENYL)-1H-PYRAZOLE-4-CARBONITRILE
• Synonyms: BUTTPARK 87\09-39;5-AMINO-1-(4-BROMOPHENYL)-1H-PYRAZOLE-4-CARBONITRILE;5-Amino-1-(4-bromophenyl)
• CAS NO: 5334-28-1
• Molecular Formula: C₁₀H₇BrN₄
• Molecular Weight: 263.09
• Mol File: 5334-28-1.mol
• Article Data: 14

Chemical Properties

• Melting Point: 168-170℃
• Boiling Point: 440.6 °C at 760 mmHg
• Flash Point: 220.3 °C
• Appearance: /
• Density: 1.66
• Vapor Pressure: 5.82E-08mmHg at 25°C
• Refractive Index: 1.711
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 5-AMINO-1-(4-BROMOPHENYL)-1H-PYRAZOLE-4-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-1-(4-BROMOPHENYL)-1H-PYRAZOLE-4-CARBONITRILE(5334-28-1)
• EPA Substance Registry System: 5-AMINO-1-(4-BROMOPHENYL)-1H-PYRAZOLE-4-CARBONITRILE(5334-28-1)

Safety Data

• Hazardous Substances Data: 5334-28-1(Hazardous Substances Data)

Usage

General Description

5-AMINO-1-(4-BROMOPHENYL)-1H-PYRAZOLE-4-CARBONITRILE is a chemical compound with the molecular formula C10H7BrN4. It is a pyrazole derivative with a carbonitrile group attached to the 4 position of the pyrazole ring and an amino group attached to the 5 position. The compound also contains a 4-bromophenyl group attached to the 1 position of the pyrazole ring. This chemical may have potential applications in pharmaceutical research and development, particularly in the synthesis of new drug candidates or as a building block in organic synthesis. Its precise properties and uses would need to be further investigated through research and experimentation.

InChI:InChI=1/C10H7BrN4/c11-8-1-3-9(4-2-8)15-10(13)7(5-12)6-14-15/h1-4,6H,13H2

Upstream product

• 122-51-0 orthoformic acid triethyl ester 
• 589-21-9 (4-bromophenyl)hydrazine 
• 109-77-3 malononitrile 
• 123-06-8 Ethoxymethylenemalononitrile 
• 106-40-1 4-bromo-aniline 
• 622-88-8 4-bromophenylhydrazine hydrochloride 

Downstream Products

• 135108-56-4 4-Amino-1-(4-bromo-phenyl)-5-methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-6-one 
• 50427-80-0 5-amino-1-(4-bromophenyl)-1H-pyrazole-4-carboxamide 
• 1094618-83-3 1-(4-bromophenyl)-5,6,7,8-tetrahydro-1H-pyrazolo[3,4-b]quinolin-4-amine 
• 1301185-10-3 1-(4-bromophenyl)-1H-pyrazole-4-carboximidamide 
• 1350554-96-9 1-(4-bromophenyl)-4-(4,5-dihydro-1H-imidazol-2-yl)-1H-pyrazole 
• 1350555-01-9 5-amino-1-(4-bromophenyl)-4-(4,5-dihydro-1H-imidazol-2-yl)-1H-pyrazole 
• 1431459-35-6 5-[1-(4-bromophenyl)-1H-pyrazole-4-yl]-1H-tetrazole 
• 832715-52-3 4-chloro-1-(4-bromophenyl)-1H-pyrazolo[3,4-d]pyrimidine 
• 105640-81-1 1-(4-bromo-phenyl)-4-chloro-6-methyl-1H-pyrazolo[3,4-d]pyrimidine 
• 864872-05-9 1-(4-bromo-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 100124-24-1 1-(4-bromo-phenyl)-6-methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 

Relevant articles and documents

Synthesis of pyrazole-carboxamides and pyrazole-carboxylic acids derivatives: Simple methods to access powerful building blocks

Hybrid systems containing pyrazole moiety show a wide spectrum of biological activities. To access novel hybrids with pyrazole ring, in this work we synthesized twenty pyrazole-carboxylic acids and twenty pyrazole-carboxamides, using simple synthetic methods, to be used as building blocks in the development of new structures.

A Convenient Synthesis of Pyrazole-imidazoline Derivatives by Microwave Irradiation

A series of 28 hybrids pyrazole-imidazolines 1a–n and 2a–n were synthesized by a new methodology using microwave irradiation, in short time (20–30?min), in low power (50–70?W), and in 34–92% yield. Among all methodologies evaluated, no side products were obtained. All derivatives were completely characterized by FT–IR, 1H and 13C NMR, GC–MS, and HRMS.

Synthesis and Biological Activity of Amide Compounds Containing Pyrazole Mandelic Acid Groups

A series of novel mandelic acid pyrazole amide compounds were synthesized and characterized. Moreover, their antiviral activities against tobacco mosaic virus were evaluated. The bioassay results indicated that as-prepared compounds showed antiviral activity against tobacco mosaic virus at a concentration of 500?g/mL. The curative activity of compound 4g is 59.5%, which was comparable with positive control (Ningnanmycin, 61.0%). The inactivation activity of the compound 4l exhibited 80.1%, which was higher than that of Ningnanmycin (75.0%), and its protective activity was 88.7%, which is comparable with that of Ningnanmycin (90.7%).