5337-45-1 Usage
Description
(3beta,5alpha,6beta)-5,6-dibromo-3-chlorocholestane is a steroidal compound belonging to the class of cholestanes, characterized by a 27-carbon skeleton and the specific arrangement of two bromine atoms and one chlorine atom. This unique structure endows the compound with distinct chemical properties, making it valuable for various chemical reactions and processes. It holds significant relevance in the field of organic chemistry, particularly in the study of steroidal compounds and their derivatives, and is of interest to researchers for its potential implications in chemical and biological processes.
Uses
Used in Chemical Reactions and Processes:
(3beta,5alpha,6beta)-5,6-dibromo-3-chlorocholestane is used as a reactant in various chemical reactions due to its unique structure and properties. The specific arrangement of bromine and chlorine atoms allows for targeted functionalization and modification, making it a versatile building block in organic synthesis.
Used in Organic Chemistry Research:
In the field of organic chemistry, (3beta,5alpha,6beta)-5,6-dibromo-3-chlorocholestane serves as a model compound for studying the behavior and reactivity of steroidal compounds. Its unique structure provides insights into the effects of halogen substitution on the chemical properties of cholestanes, contributing to the broader understanding of steroidal chemistry.
Used in Pharmaceutical Development:
(3beta,5alpha,6beta)-5,6-dibromo-3-chlorocholestane may be used as a starting material or intermediate in the development of pharmaceuticals targeting steroid hormone receptors or other related biological processes. Its unique chemical properties could be exploited to design novel drugs with improved efficacy and selectivity.
Used in Material Science:
(3beta,5alpha,6beta)-5,6-dibromo-3-chlorocholestane's unique structure and properties may also find applications in material science, potentially leading to the development of new materials with specific properties, such as improved stability or reactivity under certain conditions.
Used in Environmental Applications:
(3beta,5alpha,6beta)-5,6-dibromo-3-chlorocholestane could be utilized in environmental applications, such as the remediation of contaminated sites or the development of new methods for detecting and monitoring the presence of steroidal compounds in the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 5337-45-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,3 and 7 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 5337-45:
(6*5)+(5*3)+(4*3)+(3*7)+(2*4)+(1*5)=91
91 % 10 = 1
So 5337-45-1 is a valid CAS Registry Number.
5337-45-1Relevant articles and documents
Electrochemical bromination of cholest-5-enes
Milisavljevic, Smiljka S.,Wurst, Klaus,Laus, Gerhard,Vukicevic, Mirjana D.,Vukicevic, Rastko D.
, p. 867 - 872 (2007/10/03)
Four 5,6-unsaturated steroids - 3β-chlorocholest-5-ene (1a), cholesterol (1b) and its acetate (1c) and benzoate (1d) - were subjected to constant current electrolysis (50 mA, 2 F mol-1) in an electrolytic cell divided by a ceramic membrane, using a platinum foil as the anode and a graphite stick as the cathode. When electrolysis was carried out in a solution of tetraethylammonium bromide in aprotic solvents (dichloromethane, acetonitrile or acetic anhydride), the addition of electrochemically-generated elemental bromine onto the double bond of the cholesterol derivatives gave their corresponding 5α,6β-dibromosteroids - 3β-chloro-5α, 6β-dibromocholestane (2a), 5α,6β-dibromocholestan-3β-ol (2b), 5α,6β-dibromocholestan-3β-yl acetate (2c) and 5α,6β-dibromocholestan-3β-yl benzoate (2d) - as the sole products, and in good yields (58-91%). However, the electrolysis of steroids 1a-c in a solution of tetraethylammonium bromide with methanol as the solvent proceeded to give, in addition to dibromides 2a-c, the corresponding diastereomeric pairs of 5-bromo-6-methoxysteroids: 5α-bromo-3β- chloro-6β-methoxycholestane (3a) and 5β-bromo-3β-chloro-6α- methoxycholestane (4a), 5α-bromo-6β-methoxycholestan-3β-ol (3b) and 5β-bromo-6α-methoxycholestan-3β-ol (4b) and 5α-bromo-6β-methoxycholestan-3β-yl acetate (3c) and 5α-bromo-6β-methoxycholestan-3β-yl acetate (4c). The benzoate 1d was not soluble enough in methanol, even with heating. The products were characterized by physical and spectral data (IR, 1H NMR and 13C NMR). Single crystal X-ray structure determinations of compounds 2a and 3a are also reported.
