5338-16-9

Basic information

• Product Name: GUANYLUREA SULFATE
• Synonyms: AMIDINOUREA SULFATE;DICYANDIAMIDINE SULFATE;GUANYLUREA SULFATE;GUANYLUREA SULPHATE;CARBAMOYLGUANIDINE SULFATE;N-GUANYLUREA SULFATE;amidinouronium hydrogen sulphate;GUANYLUREA SULFATE 98+%
• CAS NO: 5338-16-9
• Molecular Formula: C₂H₆N₄O*H₂O₄S
• Molecular Weight: 302.27
• EINECS: 209-697-8
• Mol File: 5338-16-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 190 °C
• Boiling Point: 550°C at 760 mmHg
• Flash Point: 286.4°C
• Appearance: /
• Vapor Pressure: 1.51E-13mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Water (Slightly)
• CAS DataBase Reference: GUANYLUREA SULFATE(CAS DataBase Reference)
• NIST Chemistry Reference: GUANYLUREA SULFATE(5338-16-9)
• EPA Substance Registry System: GUANYLUREA SULFATE(5338-16-9)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 5338-16-9(Hazardous Substances Data)

Usage

Description

GUANYLUREA SULFATE, a white powder with a purity of greater than 97%, is a chemical compound known for its solubility in water and alcohol. It is a versatile substance with various applications across different industries due to its unique chemical properties.

Uses

Used in Analytical Chemistry:
GUANYLUREA SULFATE is used as an analytical reagent for the detection and measurement of nickel. Its chemical properties make it suitable for this application, allowing for accurate and reliable results in the analysis of nickel content in various samples.
Used in Dye Manufacturing:
In the dye industry, GUANYLUREA SULFATE serves as a crucial component in the manufacturing process of dyes. Its chemical structure contributes to the development of dyes with specific properties, such as color intensity and stability, making it an essential ingredient in the production of a wide range of dyes.
Used in Organic Synthesis:
GUANYLUREA SULFATE is also utilized in organic synthesis, where it acts as a key building block for the creation of various organic compounds. Its reactivity and solubility properties enable chemists to synthesize a diverse array of organic molecules, contributing to the development of new materials and pharmaceuticals.

InChI:InChI=1/C2H6N4O.H2O4S/c3-1(4)6-2(5)7;1-5(2,3)4/h(H6,3,4,5,6,7);(H2,1,2,3,4)/p-1

Upstream product

• 127099-85-8 N-Cyanoguanidine 

Downstream Products

• 594-14-9 guanidinium sulfate 
• 103-03-7 1-phenylsemicarbazide 
• 97149-65-0 1-1-(anilinothioformyl)amidino>urea 
• 141-83-3 carbamimidoylurea 
• 603-54-3 N,N-diphenylurea 
• 38261-35-7 6-amino-4-phenyl-3,4-dihydro-1,3,5-triazin-2(1H)-one 
• 38261-33-5 6-amino-4-(4-(dimethylamino)phenyl)-3,4-dihydro-1,3,5-triazin-2(1H)-one 
• 38261-34-6 6-amino-4-p-tolyl-3,4-dihydro-1,3,5-triazin-2(1H)-one 

Relevant articles and documents

Multitarget drug discovery for Alzheimer's disease: Triazinones as BACE-1 and GSK-3β inhibitors

Cumulative evidence strongly supports that the amyloid and tau hypotheses are not mutually exclusive, but concomitantly contribute to neurodegeneration in Alzheimer's disease (AD). Thus, the development of multitarget drugs which are involved in both pathways might represent a promising therapeutic strategy. Accordingly, reported here in is the discovery of 6-amino-4-phenyl-3, 4-dihydro-1, 3, 5-triazin-2(1H)-ones as the first class of molecules able to simultaneously modulate BACE-1 and GSK-3β. Notably, one triazinone showed well-balanced in vitro potencies against the two enzymes (IC50 of (18.03 ±0.01) μM and (14.67±0.78)μUM for BACE-1 and GSK-3β, respectively). In cell-based assays, it displayed effective neuroprotective and neurogenic activities and no neurotoxicity. It also showed good brain permeability in a preliminary pharmacokinetic assessment in mice. Overall, triazinones might represent a promising starting point towards high quality lead compounds with an AD-modifying potential.