53385-83-4

Basic information

• Product Name: Thiourea, N-(6-methyl-2-pyridinyl)-N'-phenyl-
• CAS NO: 53385-83-4
• Molecular Formula: C13H13N3S
• Molecular Weight: 243.332
• Mol File: 53385-83-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Thiourea, N-(6-methyl-2-pyridinyl)-N'-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiourea, N-(6-methyl-2-pyridinyl)-N'-phenyl-(53385-83-4)
• EPA Substance Registry System: Thiourea, N-(6-methyl-2-pyridinyl)-N'-phenyl-(53385-83-4)

Safety Data

• Hazardous Substances Data: 53385-83-4(Hazardous Substances Data)

Upstream product

• 109-06-8 α-picoline 
• 1824-81-3 2-Amino-6-methylpyridine 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 129915-52-2 Hg(N-2-(6-methylpyridyl)-N'-phenylthiourea)2Cl₂ 
• 124719-60-4 Co(N-2-(6-methylpyridyl)-N'-phenylthiourea)2Cl₂ 
• 80291-23-2 VOCl₃(CH₃C₅NH₃NHCSNHC₆H₅) 
• 100856-68-6 (5-Methyl-thiazolo[4,5-b]pyridin-2-yl)-phenyl-amine 
• 91597-29-4 N-(6-methyl-[2]pyridyl)-N'-phenyl-urea 
• 1109168-41-3 4-hydroxy-4-methoxycarbonyl-3,5-diphenyl-2-(3-methylpyridin-2-ylimino)thiazolidine 

Relevant articles and documents

Design, synthesis, DNA assessment and molecular docking study of novel 2-(pyridin-2-ylimino)thiazolidin-4-one derivatives as potent antifungal agents

A series of novel 2-imino-4-thiazolidinone derivatives 4a,b was synthesized through reaction of unsymmetrical thioureas 3a,b with chloroacetic acid. Condensation of 4a,b with aromatic aldehydes 5a-eyielded the corresponding 5-arylidene derivatives 6a-j. In addition, the reaction of 4a,b with 4-arylazo-3-hydroxybenzaldehydes 8a-c furnished the respective mono-arylazo-4-thiazolidinones10a-f. All the newly synthesized compounds were confirmed by their elemental analysis and spectral data. The antifungal activity of the newly synthesized compounds was assessed and the compounds 6d, 6e, 6i, 6j, 9a,b and 10a-frevealedhigher antifungal activity towards Alternaria solani than to the standard Ridomil gold plus. Moreover, the DNA toxicity of 4-thiazolidinone derivatives 6d, 9a, 10b, 10c and 10f on the nucleic acid of Alternaria solani (KT354939) was performed and the results showed qualitatively more than 70% cleavage. Also, compounds 6i, 6j, 9b, 10c and 10f were docked inside the active site of 1ZOYenzyme and suitable binding with the active site of amino acids, were displayed according to their bond lengths, angles and conformational energy.

2-aminothiazoles as therapeutic leads for prion diseases

2-Aminothiazoles are a new class of small molecules with antiprion activity in prion-infected neuroblastoma cell lines (J. Virol. 2010, 84, 3408). We report here structure-activity studies undertaken to improve the potency and physiochemical properties of 2-aminothiazoles, with a particular emphasis on achieving and sustaining high drug concentrations in the brain. The results of this effort include the generation of informative structure-activity relationships (SAR) and the identification of lead compounds that are orally absorbed and achieve high brain concentrations in animals. The new aminothiazole analogue (5-methylpyridin-2-yl)-[4-(3-phenylisoxazol-5-yl)-thiazol-2-yl]-amine (27), for example, exhibited an EC50 of 0.94 μM in prion-infected neuroblastoma cells (ScN2a-cl3) and reached a concentration of ～25 μM in the brains of mice following three days of oral administration in a rodent liquid diet. The studies described herein suggest 2-aminothiazoles as promising new leads in the search for effective therapeutics for prion diseases.

Synthesis and antimicrobial activity of pyridines bearing thiazoline and thiazolidinone moieties

Two series of new pyridines bearing thiazoline (3a - n) and thiazolidinone (5a - e) moieties were prepared via the cyclization of the corresponding substituted pyridyl thiourea (2a - g) with an appropriately substituted phenacyl bromide or chloroacetic ac